How to Perform IVIVC for Extremely Long Acting Drugs
Watch this webinar to learn how to use in vitro and in vivo models to find direct time scaling factors and confirm the similarity of the in vitro and in vivo release mechanisms.
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How to Use a Reference-scaled Average Bioequivalence Approach for Narrow Therapeutic Index Drugs
Watch this webinar to learn how RSABE for NTIDs can be performed in Phoenix WinNonlin using a reusable template.
Validation Made Easier! Tips and Guidance from the Experts
In this webinar, Noreen Muscat from QACV Consulting discussed common pitfalls in validation and how to avoid them, and Allan Michaels, Sr. Project Manager of Phoenix Technology Services, shared how the latest Validation Suite for Phoenix WinNonlin expedites validation and provides robust reporting.
Accomplish More with Phoenix—New Phoenix 8.1 Release in June 2018!
As the gold standard for PK/PD software, our upcoming Phoenix 8.1 release delivers new capabilities to automate processes, reduce errors, and save you time. Dr. Nathan Teuscher, VP of Pharmacometric Consulting, Venkateswari Muthukrishnan, Phoenix WinNonlin Product Manager, and Ana Henry, Executive Director of Training, shared our latest innovations in WinNonlin and NLME and conducted a live demo.
Speaker(s): Nathan Teuscher, Venkateswari Muthukrishnan, Ana Henry
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Solution:
PK/PD Modeling & Simulation
Making Sense of 6MWT Variability: Developing a Disease Progression Model for Duchenne Muscular Dystrophy
Watch this webinar with Drs. Lora Hamuro and Joga Gobburu to learn how they developed a natural history progression model for DMD using the 6MWT.
Speaker(s): Lora Hamuro, Joga Gobburu
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Solution:
PK/PD Modeling & Simulation
Therapeutic Area:
Pediatrics, Rare/Orphan Disease
Estimating the Number of Transit Compartments Using a Distributed Delay Model
Watch this webinar to learn how the delay operator implemented in Phoenix 8 can eliminate the need to add complex lines of code for each delay differential equation, simplify modeling delayed outcomes, and avoid inefficient workarounds and approximations.
Speaker(s): Wojciech Krzyzanski
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Solution:
PK/PD Modeling & Simulation
Therapeutic Area:
Oncology/Hematology
Using PML to Perform Mechanistic Pharmacokinetic Modeling
Watch this webinar with Cen Guo—a graduate student at UNC-Chapel Hill—to learn how she used an integrated approach to predict alterations in bile acid disposition due to inhibition of multiple transporters using the model bile acid taurocholate (TCA).
How to Perform Level C IVIVC in Phoenix
In this webinar, Professor Jean-Michel Cardot explained how to perform Level C IVIVC using Phoenix. Learn how to calculate pharmacokinetic parameters via the non-compartmental analysis module; how to calculate dissolution parameters via the dissolution module; how to link the in vivo pharmacokinetic parameters and in vitro dissolution parameters via the linear relationship module; and how to calculate dissolution limits.
How Can You Get the Most out of Phoenix 8.0?
In this webinar, Dr. Nathan Teuscher demonstrated how to get the most out of Phoenix 8.0’s new features, including how to automatically calculate new NCA parameters, set up parallelization of Phoenix NLME runs, and leverage the new validation suite to get up and running in no time.
Non-linear Time Scaling for IVIVC: Secrets from an Expert
Learn how non-parametric approaches can be used to determine time scaling for in vitro-in vivo correlation (IVIVC).
Speaker(s): Jean-Michel Cardot
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Solution:
Model-informed Drug Development, PK/PD Modeling & Simulation