Quantitative Systems Toxicology Approach Integrates Simcyp PBPK and Core Hepatocyte Metabolism: a Case Study with Valproic Acid
Organ-on-chip systems aim to recapitulate human physiology in vitro and hold the promise to revolutionize drug development.
Quantitative description of the physiological changes in diseased skin and their incorporation into Physiologically Based Pharmacokinetic Models.
A comparison of two model reduction methodologies for a QSP bone biology system with denosumab dosing
QSP Modelling of Neurodegenerative Chronic Diseases and Brain Biomarkers: Adding the Effect of Ageing on Brain Volume
Clinical validation of a quantitative systems pharmacology (QSP) model for nerve-growth factor (NGF) therapies
This webinar discussed which pharmaceutical payer strategies work and which don’t in our rapidly changing regulatory and reimbursement world.
Immuno-oncology – The Breakthrough in Cancer Therapeutics Cancer immuno-oncology (IO) uses the body’s natural defenses to combat cancer. These therapies stimulate an individual’s immune system and restore its ability to identify and destroy cancer cells. Anti-cancer immune responses are often inhibited during the spread of cancer. Ultimately, IO therapy expedites long term responses against cancer […]
A Quantitative Systems Pharmacology (QSP) approach for developing combination immune-oncology therapies can be used to better predict effective drug combinations, especially to more accurately correlate the physiological differences between preclinical models and human patients.