PBPK Modeling & Simulation

Modeling the Influence of Ethnicity on Drug Disposition

Zoe Barter

Ever noticed how people from different ethnic backgrounds respond differently to drugs? For example, you may enjoy having a few drinks with friends on the weekend.  When your friends with Eastern Asian heritage drink alcohol, it’s not uncommon for their faces to turn red. This happens because many East Asians possess an enzyme deficiency for […]

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Topics: PBPK Modeling & Simulation

Assessing the Impact of Liver or Kidney Disease on Pharmacokinetics

Trevor Johnson

Impaired hepatic or renal function can have a major impact on pharmacokinetics. There is a high risk of adverse events in patients with these conditions. Major pharmaceutical companies and drug regulatory agencies use physiologically-based pharmacokinetic (PBPK) modeling in virtual populations to investigate the impact of hepatic or renal impairment on drug exposure as a supplement to […]

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Topics: PBPK Modeling & Simulation

Postcards from the Road: Phoenix Fall Tour

Ana Henry

We’ve just returned from the third leg of our now annual Phoenix roadshow. In this leg, I helped deliver workshops in Beijing, Osaka and Tokyo. In total, our product development team has visited eight cities in the US, Europe and Asia.  We gave both technical and scientific PK/PD modeling presentations to more than 250 clients. […]

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Topics: PK/PD Modeling & Simulation

9 Frequently Misunderstood Concepts in PK/PD Modeling

Nathan Teuscher

In teaching pharmacometrics, I’ve noticed that scientists have difficulty with certain PK/PD modeling concepts. Maybe you’ve read about some of these terms in journal articles, but didn’t know what they meant? Or you’ve heard these terms bandied about by colleagues, but felt too shy to ask them what they meant? I’ll clarify some important concepts […]

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Topics: PK/PD Modeling & Simulation
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