Radiometric Analysis
One of the oldest methods used for the quantitation of drug molecules is radiometric analysis.…
CertaraJuly 29, 2014
FDA JumpStart: an introduction
Discover FDA JumpStart, a ground-breaking service accelerating drug reviews by enhancing data quality, identifying risks,…
CertaraJuly 16, 2014
Understanding LC/MS/MS
The most common bioanalytical method in use today is LC/MS/MS, or liquid chromatography (LC) tandem…
CertaraJuly 15, 2014
Population Pharmacokinetic Analysis of Dutogliptin, a Selective Dipeptidyl Peptidase-4 Inhibitor
Dutogliptin is a selective dipeptidyl peptidase-4 inhibitor shown to be efficacious and safe in patients…
CertaraJuly 14, 2014
Simulation of Monoclonal Antibody Pharmacokinetics in Humans Using a Minimal Physiologically-based Model
Compared to small chemical molecules, antibodies and Fc-containing derivatives (mAbs) have unique pharmacokinetic behavior characterized by…
CertaraJuly 9, 2014
Application of a Physiologically-based Pharmacokinetic Model to Predict OATP1B1-related Variability in Pharmacodynamics of Rosuvastatin
Typically, pharmacokinetic-pharmacodynamic (PK/PD) models use plasma concentration as the input that drives the PD model. However, interindividual variability in…
CertaraJuly 9, 2014
What is HPLC/UV?
In my series about bioanalysis for the pharmacokineticist, I thought I would start with the…
CertaraJuly 8, 2014
Model of the Distribution of Diastolic Left Ventricular Posterior Wall Thickness in Healthy Adults and Its Impact on the Behavior of a String of Virtual Cardiomyocytes
Correlation of the thickness of the left ventricular posterior wall (LVPWd) with various parameters, including…
CertaraJuly 1, 2014
A Re-evaluation and Validation of Ontogeny Functions for CYPs 1A2 and 3A4 Based on In Vivo Data
Current cytochrome P450 (CYP) 1A2 and 3A4 ontogeny profiles, which are derived mainly from in…
CertaraJuly 1, 2014
