Application of Knockout Mouse Models to Investigate the Influence of FcγR on the Pharmacokinetics and Anti-platelet Effects of MWReg30, a Monoclonal Anti-GPIIb Antibody Publication Application of Knockout Mouse Models to Investigate the Influence of FcγR on the Pharmacokinetics and Anti-platelet Effects of MWReg30, a Monoclonal Anti-GPIIb Antibody This work evaluates the influence of FcγR on the pharmacokinetics and pharmacodynamics of a rat…CertaraFebruary 28, 2013
Saturable Drug Absorption Knowledge Base Saturable Drug Absorption Drug absorption is the process by which a drug molecule moves from the site of…CertaraFebruary 26, 2013
Systems Pharmacology of the Nerve Growth Factor Pathway: Use of a Systems Biology Model for the Identification of Key Drug Targets Using Sensitivity Analysis and the Integration of Physiology and Pharmacology Publication Systems Pharmacology of the Nerve Growth Factor Pathway: Use of a Systems Biology Model for the Identification of Key Drug Targets Using Sensitivity Analysis and the Integration of Physiology and Pharmacology The nerve growth factor (NGF) pathway is of great interest as a potential source of…CertaraFebruary 21, 2013
Systems Pharmacology for Drug Discovery and Development: Paradigm Shift or Flash in the Pan? Publication Systems Pharmacology for Drug Discovery and Development: Paradigm Shift or Flash in the Pan? Systems pharmacology is an emerging approach that sets out to use quantitative concepts rooted in…CertaraFebruary 20, 2013
Nonlinear PK: What Does That Mean? BlogKnowledge Base Nonlinear PK: What Does That Mean? You may come across a phrase like the following and wonder what it means: “……CertaraFebruary 17, 2013
Why Cmax is a Continuous Variable and Tmax is a Categorical Variable Knowledge Base Why Cmax is a Continuous Variable and Tmax is a Categorical Variable The maximum observed concentration (Cmax) and the time of Cmax (tmax) are both obtained directly…CertaraFebruary 11, 2013
What is Quantification Anyway? Knowledge Base What is Quantification Anyway? Bioanalytical analysis is a fundamental tool for the pharmacokineticist. The results of a bioanalysis are…CertaraFebruary 5, 2013
Inhibitory Effect of Ketoconazole on the Pharmacokinetics of a Multireceptor Tyrosine Kinase Inhibitor BMS-690514 in Healthy Participants: Assessing the Mechanism of the Interaction with Physiologically-based Pharmacokinetic Simulations Publication Inhibitory Effect of Ketoconazole on the Pharmacokinetics of a Multireceptor Tyrosine Kinase Inhibitor BMS-690514 in Healthy Participants: Assessing the Mechanism of the Interaction with Physiologically-based Pharmacokinetic Simulations BMS-690514, a selective inhibitor of the ErbB and vascular endothelial growth factor receptors, has shown…CertaraFebruary 1, 2013
Bioavailability of Intranasal vs. Rectal Diazepam Publication Bioavailability of Intranasal vs. Rectal Diazepam There remains an unmet medical need in the out-of-hospital management of seizure emergencies because older…CertaraFebruary 1, 2013
Pharmacokinetics, Pharmacodynamics, Physiologically-based Pharmacokinetic Modeling of Monoclonal Antibodies Publication Pharmacokinetics, Pharmacodynamics, Physiologically-based Pharmacokinetic Modeling of Monoclonal Antibodies Development of monoclonal antibodies (mAbs) and their functional derivatives represents a growing segment of the…CertaraFebruary 1, 2013