PK/PD Modeling & Simulation

Absorption Rate

Nathan Teuscher

The rate at which a drug enters the body after administration is called the absorption rate, and is represented by the symbol ka. This is probably one of the simplest pharmacokinetic (PK) parameters to explain and understand. Let’s consider the case of oral administration first, then we can discuss other routes of administration. A drug […]

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Topics: PK/PD Modeling & Simulation

Bioavailability and Your Pay Stub

Nathan Teuscher

Bioavailability is another primary pharmacokinetic parameter (like Clearance and Volume of Distribution) that describes the fraction of administered drug that reaches the systemic circulation. As a fraction, bioavailability can take any real value between 0 and 1 (e.g. 0.54). Sometimes this is reported as a percentage instead of a decimal (e.g. 54%). To explain this, […]

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Topics: PK/PD Modeling & Simulation

What is a Half-life?

Nathan Teuscher

One of the most incorrectly used but most often quoted parameters is half life. The symbol for half-life is t1/2. The reason for the multitude of errors with half-life is that in most cases, the assumptions required to use half-life correctly are rarely valid. And when the assumptions are false, the derived interpretations are also […]

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Topics: PK/PD Modeling & Simulation
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