Absorption Rate
The rate at which a drug enters the body after administration is called the absorption…
CertaraDecember 30, 2010
PBPK Modeling of Inter-individual Variability in the Pharmacokinetics of Environmental Chemicals
Generic PBPK models, applicable to a large number of substances, coupled to parameter databases and…
CertaraDecember 30, 2010
What is a Half-life?
One of the most incorrectly used but most often quoted parameters is half life. The…
CertaraDecember 20, 2010
Modeling Disease Progression in Acute Stroke Using Clinical Assessment Scales
This article demonstrates techniques for describing and predicting disease progression in acute stroke by modeling…
CertaraDecember 1, 2010
Determination of a Quantitative Relationship Between Hepatic CYP3A5*1/*3 and CYP3A4 Expression for Use in the Prediction of Metabolic Clearance in Virtual Populations
The creation of virtual populations allows the estimation of pharmacokinetic parameters, such as metabolic clearance…
CertaraNovember 1, 2010
Population Pharmacokinetic/Pharmacodynamic Modeling for the Time Course of Tumor Shrinkage by Motesanib in Thyroid Cancer Patients
To develop a population pharmacokinetic/pharmacodynamic model describing the relationship between motesanib exposure and tumor response…
CertaraNovember 1, 2010
Development of a Modeling Framework to Simulate Efficacy Endpoints for Motesanib in Thyroid Cancer Patients
To develop a modeling framework that simulates clinical endpoints (objective response rate and progression-free survival)…
CertaraNovember 1, 2010
Incorporating Human Dosimetry and Exposure into High-throughput In Vitro Toxicity Screening
Many chemicals in commerce today have undergone limited or no safety testing. To reduce the…
CertaraOctober 1, 2010
Randomised, Parallel-group, Multicenter, Multinational Phase 2 Study Comparing Edoxaban, an Oral Factor Xa Inhibitor, with Warfarin for Stroke Prevention in Patients with Atrial Fibrillation
The primary objective of this study was to compare the safety of four fixed-dose regimens…
CertaraSeptember 10, 2010
Mechanistic Toxicokinetic Model for γ-Hydroxybutyric Acid: Inhibition of Active Renal Reabsorption as a Potential Therapeutic Strategy
γ-Hydroxybutyric acid (GHB), a drug of abuse, exhibits saturable renal clearance and capacity-limited metabolism. The …
CertaraSeptember 1, 2010
