Artificial Intelligence: What is it & how can it accelerate rare disease drug development? Blog Artificial Intelligence: What is it & how can it accelerate rare disease drug development? Large & complex information streams present opportunities for the AI data scientist to aid in…CertaraFebruary 3, 2023
Using Modeling & Simulation to Develop a Dosing Regimen for a Bispecific Antibody for Pediatric Cancer Case Study Using Modeling & Simulation to Develop a Dosing Regimen for a Bispecific Antibody for Pediatric Cancer Bispecific antibodies are an emerging class of antibodies developed in recent years that provide new…CertaraJanuary 23, 2023
Simcyp Simulator Helps Optimize Drug Dosing in Adults & Adolescents with Orphan Disease Case Study Simcyp Simulator Helps Optimize Drug Dosing in Adults & Adolescents with Orphan Disease Congenital adrenal hyperplasia (CAH) affects about 400,000 patients worldwide. Current therapy for CAH uses a…CertaraJune 6, 2022
PBPK Modeling in Adults Enables DDI Risk Assessment in Children with SMA Case Study PBPK Modeling in Adults Enables DDI Risk Assessment in Children with SMA In 2020, the US FDA approved Risdiplam (Evrysdi®) as the first orally administered drug to…CertaraJune 2, 2022
Leveraging Clinical Data from One Rare Disease to Support Drug Approval for Another Case Study Leveraging Clinical Data from One Rare Disease to Support Drug Approval for Another Atypical hemolytic uremic syndrome (aHUS) is an ultra-rare genetic disease that causes abnormal blood clot…CertaraJune 1, 2022
PBPK Model Informs Antibody-Drug Conjugate Label for DDIs Without Clinical Trials Case Study PBPK Model Informs Antibody-Drug Conjugate Label for DDIs Without Clinical Trials Genentech was developing polatuzumab vedotin (Polivy), an anti-CD79b-vc-monomethyl auristatin E (MMAE) antibody-drug conjugate (ADC) to…CertaraApril 11, 2022
What is the FDA’s Project Optimus & How Will it Affect Oncology Drug Development? Blog What is the FDA’s Project Optimus & How Will it Affect Oncology Drug Development? Project Optimus is an initiative proposed by the U.S. Food and Drug Administration’s Oncology Center…CertaraFebruary 2, 2022
What Oncology Drug Developers Should Expect from the FDA’s Project Optimus On-Demand Webinar What Oncology Drug Developers Should Expect from the FDA’s Project Optimus Historically, the dosing strategy for oncology drugs has focused on the maximum tolerated dose. This…CertaraJanuary 13, 2022
PBPK Modeling of Antibody-Drug Conjugates – Concept and Application On-Demand Webinar PBPK Modeling of Antibody-Drug Conjugates – Concept and Application Antibody-Drug Conjugates (ADCs) can be an ideal drug treatment for cancer because they deliver a…CertaraJanuary 13, 2022