DEVELOPMENT OF A PBPK MODEL FOR EFAVIRENZ THAT ACCOUNTS FOR AUTO-INDUCTION AND ITS EFFECT ON THE CYP2B6 SUBSTRATE BUPROPION Poster DEVELOPMENT OF A PBPK MODEL FOR EFAVIRENZ THAT ACCOUNTS FOR AUTO-INDUCTION AND ITS EFFECT ON THE CYP2B6 SUBSTRATE BUPROPION CertaraAugust 23, 2019
Prediction of Midazolam Pharmacokinetics in Pregnant Women with Coeliac Disease using Simcyp Pregnancy PBPK Model Poster Prediction of Midazolam Pharmacokinetics in Pregnant Women with Coeliac Disease using Simcyp Pregnancy PBPK Model CertaraAugust 23, 2019
Investigating Impacts of Model Parameters Correlations in Global Sensitivity Analysis: Determining the Most Influential Parameters of a Minimal PBPK Model of Midazolam Poster Investigating Impacts of Model Parameters Correlations in Global Sensitivity Analysis: Determining the Most Influential Parameters of a Minimal PBPK Model of Midazolam CertaraJune 24, 2019
PBPK’s Pivotal Role in Modern Drug Development: Busting Common Myths and Misconceptions White Paper PBPK’s Pivotal Role in Modern Drug Development: Busting Common Myths and Misconceptions This white paper addresses common PBPK myths and misconceptions and demonstrates how this approach is…CertaraFebruary 4, 2019
Using PBPK Models to Assess Fetal Drug Exposure Blog Using PBPK Models to Assess Fetal Drug Exposure The tragedy of thalidomide provides a cautionary tale about the potential for birth defects resulting…CertaraJanuary 19, 2018
PBPK Modeling and Simulation for Biologics Brochure PBPK Modeling and Simulation for Biologics CertaraApril 28, 2017
Application of the MechPeff Model to Predict Passive Effective Intestinal Permeability in the Different Regions of the Rodent Small Intestine and Colon Publication Application of the MechPeff Model to Predict Passive Effective Intestinal Permeability in the Different Regions of the Rodent Small Intestine and Colon CertaraFebruary 1, 2017
Commentary on “In Silico Modeling of Gastrointestinal Drug Absorption: Predictive Performance of Three Physiologically-based Absorption Models” Publication Commentary on “In Silico Modeling of Gastrointestinal Drug Absorption: Predictive Performance of Three Physiologically-based Absorption Models” CertaraJanuary 1, 2017
Assessing Drug-Smoking Interactions Using PBPK Modeling Blog Assessing Drug-Smoking Interactions Using PBPK Modeling The prevalence of cigarette smoking remains high globally despite abundant evidence showing that it isn't…CertaraJuly 29, 2016
Towards a Best Practice Approach in PBPK Modeling: Case Example of Developing a Unified Efavirenz Model Accounting for Induction of CYPs 3A4 and 2B6 Publication Towards a Best Practice Approach in PBPK Modeling: Case Example of Developing a Unified Efavirenz Model Accounting for Induction of CYPs 3A4 and 2B6 CertaraJuly 20, 2016