Modeling the Influence of Ethnicity on Drug Disposition
Ever noticed how people from different ethnic backgrounds respond differently to drugs? For example, you…
CertaraNovember 23, 2015
Interplay of Metabolism and Transport in Determining Oral Drug Absorption and Gut Wall Metabolism: A Simulation Assessment Using the “Advanced Dissolution, Absorption, Metabolism (ADAM)” Model
Bioavailability of orally administered drugs can be influenced by a number of factors including release…
CertaraNovember 1, 2015
How to Optimize Your Drug Label Using Modeling and Simulation Technology
As a trained pharmacist and scientist, I think a lot about patient care and how…
CertaraSeptember 29, 2015
100 Articles That Will Help You Understand PBPK Modeling & Simulation
As a company with a strong academic foundation, our scientists actively publish the results of…
CertaraJuly 28, 2015
How to Revamp Your Approach to Conventional IVIVC Models
An IVIVC (in vitro-in vivo correlation) is a predictive mathematical model describing the relationship between…
CertaraJuly 21, 2015
Application of Permeability-limited Physiologically-based Pharmacokinetic Models: Part I—Digoxin Pharmacokinetic Incorporating P-glycoprotein-mediated Efflux
A prerequisite for the prediction of the magnitude of P-glycoprotein (P-gp)-mediated drug-drug interactions between digoxin…
CertaraSeptember 1, 2013
Application of Permeability-limited Physiologically-based Pharmacokinetic Models: Part II—Prediction of P-glycoprotein Mediated Drug-drug Interactions with Digoxin
Digoxin is the recommended substrate for assessment of P-glycoprotein (P-gp)-mediated drug-drug interactions (DDIs) in vivo.…
CertaraSeptember 1, 2013
Application of In Vitro-In Vivo Extrapolation (IVIVE) and Physiologically-based Pharmacokinetic Modeling to Investigate the Impact of the CYP2C8 Polymorphism on Rosiglitazone Exposure
The purpose of this study was to predict the impact of the CYP2C8*3 genotype on…
CertaraJune 1, 2013
Physiologically-based Pharmacokinetic Models for Everolimus and Sorafenib in Mice
Everolimus is a mammalian target of rapamycin (mTOR) inhibitor approved as an immunosuppressant and for…
CertaraMay 1, 2013
