Modelling Approaches to Dose Estimation in Children
Most of the drugs on the market are originally developed for adults and dosage selection…
CertaraJune 1, 2005
Techniques: Application of Systems Biology to Absorption, Distribution, Metabolism, Excretion, and Toxicity
It is widely recognized that either predicting or determining the absorption, distribution, metabolism, excretion and…
CertaraApril 1, 2005
Does Neuromuscular Electrical Stimulation Strengthen the Quadriceps Femoris? A Systematic Review of Randomized Controlled Trials
Devices for neuromuscular electrical stimulation (NMES) are increasingly used by individuals without specific injuries and…
CertaraJanuary 1, 2005
Population Pharmacokinetics of Olmesartan Following Oral Administration of Its Prodrug, Olmesartan Medoxomil: In Healthy Volunteers and Hypertensive Patients
Olmesartan medoxomil (CS-866) is a new orally active angiotensin II receptor antagonist that is highly…
CertaraJanuary 1, 2005
Pharmacokinetics of Dibutylphthalate in Pregnant Rats
Dibutylphthalate (DBP) can cause adverse effects on the developing male reproductive tract when administered late…
CertaraDecember 1, 2004
In Silico Simulations to Assess the In Vivo Consequences of In Vitro Metabolic Drug-drug Interactions
Recently, metabolic drug-drug interactions (M-DDI) have raised some high-profile problems in drug development resulting in restricted use, withdrawal…
CertaraDecember 1, 2004
Assessment of In Vivo CYP2D6 Activity: Differential Sensitivity of Commonly Used Probes to Urine pH
Drug/metabolite ratios (MRs) are used as in vivo markers of enzyme activity. The ratios are…
CertaraDecember 1, 2004
Predicting the Clearance of CYP2C9 Substrates
Recently, Andersson et al. (2004) reported that quantitative predictions of hepatic clearance from in vitro…
CertaraDecember 1, 2004
Cytochrome P450 3A Expression and Activity in the Human Small Intestine
Recently, von Richter et al measured the content of cytochrome P450 (CYP) 3A in paired…
CertaraOctober 1, 2004
Pharmacogenetics—Expectations and Reality
Thirty years have passed since Mike Rawlins, the current chairman of the National Institute for…
CertaraJuly 1, 2004
