What to Do with Those BLQs!
BLQ values are like those pimples we used to get as teenagers. They…
CertaraApril 6, 2011
In Silico Prediction of Efavirenz and Rifampicin Drug-drug Interaction Considering Weight and CYP2B6 Phenotype
This study aimed to test whether a pharmacokinetic simulation model could extrapolate nonclinical drug data…
CertaraApril 1, 2011
Systematic Review: Diagnostic Accuracy of Clinical Decision Rules for Venous Thromboembolism in Elderly
Physicians committed to the care of elderly patients are challenged with the diagnosis of venous…
CertaraApril 1, 2011
The Difference Between Vd and Vss
There are many terms used to represent volume of distribution, but two common ones are…
CertaraMarch 31, 2011
What is Shrinkage?
In 2007, Mats Karlsson and Radojka Savic published a perspective in Clinical Pharmacology & Therapeutics…
CertaraMarch 29, 2011
Sources of Interindividual Variability in IVIVE of Clearance: An Investigation into the Prediction of Benzodiazepine Clearance Using a Mechanistic Population-based Pharmacokinetic Model
Prediction of metabolic clearance in extreme individuals rather than the 'average human' is becoming an…
CertaraMarch 24, 2011
Is a Monte Carlo Simulation an Exotic Drink?
The term “Monte Carlo simulation” is often used in the modeling and simulation literature with…
CertaraMarch 21, 2011
What is WinNonlin?
A reader suggested that I write a similar post about WinNonlin. Great idea! Thank you!…
CertaraMarch 16, 2011
What is the Difference Between Individual and Population PK?
Pharmacokinetic analysis is often broken into two areas … “PK” and “population PK”. Sometimes the…
CertaraMarch 14, 2011
Utility of Intersystem Extrapolation Factors in Early Reaction Phenotyping and the Quantitative Extrapolation of Human Liver Microsomal Intrinsic Clearance Using Recombinant Cytochromes P450
Reaction phenotyping using recombinant human cytochromes P450 (P450) has great utility in early discovery. However,…
CertaraMarch 1, 2011
