Conditional activation of IL-12 through a Fibronectin-EDB dependent switch gate
See how QSP modeling guided the design of a reversible antibody switch that unmasks IL-12…
CertaraJuly 24, 2026
Assessing Cross-Version Simcyp Simulator Prediction Performance Using a Bioequivalence Framework to Support EMA Qualification
See how Simcyp Simulator V20–V24 DDI predictions were shown equivalent to the EMA-qualified V19 using…
CertaraJuly 24, 2026
Important drug development questions that model-based meta-analysis answers
Explore drug development questions that model-based meta-analysis answers, from competitive positioning to dose selection &…
Matt Zierhut, PhD MBAJuly 23, 2026
A novel mathematical framework to predict in vivo bispecific GTX-B001 binding in skin, and translation to humans
See how quantitative pharmacology and PBPK modeling supported first in human dose selection for a…
CertaraJuly 20, 2026
Patient-Specific Determinants of Response to BCMA- and GPRC5D-Targeted CAR T-Cell Therapy in Multiple Myeloma: A QSP Analysis of Clinical Trial and Real-World Data
QSP modeling reveals patient-specific factors driving CAR T-cell response and relapse in multiple myeloma, with…
CertaraJuly 20, 2026
