Publication Archives

Publication

The Simcyp Population-based ADME Simulator

The Simcyp® population-based absorption, distribution, metabolism and excretion simulator is a platform and database for…

CertaraFebruary 6, 2009

Publication

Population Pharmacokinetics of Intravenous Pantoprazole in Pediatric Intensive Care Patients

What is already known about this subject The use of intravenous pantoprazole, a proton pump…

CertaraFebruary 1, 2009

Publication

Metabolism of Dextrorphan by CYP2D6 in Different Recombinantly Expressed Systems and Its Implications for the In Vitro Assessment of Dextromethorphan Metabolism

Cytochrome P450 2D6 (CYP2D6) mediated formation of dextrorphan (DOR) from dextromethorphan (DEX) is widely used…

CertaraFebruary 1, 2009

Publication

More Than Numbers: The Power of Graphs in Meta-analysis

In meta-analysis, the assessment of graphs is widely used in an attempt to identify or…

CertaraJanuary 15, 2009

Publication

Pharmacokinetic Predictions in Children by Using the Physiologically-based Pharmacokinetic Modeling

Nowadays, 50-90% of drugs used in children have never been actually studied in this population. Consequently, either…

CertaraDecember 1, 2008

Publication

Covariation of Human Microsomal Protein per Gram of Liver with Age: Absence of Influence of Operator and Sample Storage May Justify Interlaboratory Data Pooling

Scaling of metabolic clearance values from liver microsomal data or recombinantly expressed cytochrome P450 enzymes…

CertaraDecember 1, 2008

Publication

Pharmacokinetics, Safety, and Tolerability of Teduglutide, a Glucagon-like Peptide-2 (GLP-2) Analog, Following Multiple Ascending Subcutaneous Administrations in Healthy Subjects

Teduglutide, a glucagon-like peptide-2 (GLP-2) analog, is currently being evaluated for the treatment of short-bowel…

CertaraNovember 1, 2008

Publication

Maraviroc: In Vitro Assessment of Drug-drug Interaction Potential

AIMS: To characterize the cytochrome P450 enzyme(s) responsible for the N-dealkylation of maraviroc in vitro,…

CertaraOctober 1, 2008

Publication

Meta-analysis of the Diagnostic Accuracy of Transesophageal Echocardiography for Assessment of Atherosclerosis in the Ascending Aorta in Patients Undergoing Cardiac Surgery

Stroke after cardiac surgery may be caused by emboli emerging from an atherosclerotic ascending aorta…

CertaraOctober 1, 2008

Publication

Accurate and Interpretable Computational Modeling of Chemical Mutagenicity

We describe a method for modeling chemical mutagenicity in terms of simple rules based on…

CertaraSeptember 5, 2008

Publication

The Simcyp Population-based ADME Simulator

Population Pharmacokinetics of Intravenous Pantoprazole in Pediatric Intensive Care Patients

Metabolism of Dextrorphan by CYP2D6 in Different Recombinantly Expressed Systems and Its Implications for the In Vitro Assessment of Dextromethorphan Metabolism

More Than Numbers: The Power of Graphs in Meta-analysis

Pharmacokinetic Predictions in Children by Using the Physiologically-based Pharmacokinetic Modeling

Covariation of Human Microsomal Protein per Gram of Liver with Age: Absence of Influence of Operator and Sample Storage May Justify Interlaboratory Data Pooling

Pharmacokinetics, Safety, and Tolerability of Teduglutide, a Glucagon-like Peptide-2 (GLP-2) Analog, Following Multiple Ascending Subcutaneous Administrations in Healthy Subjects

Maraviroc: In Vitro Assessment of Drug-drug Interaction Potential

Meta-analysis of the Diagnostic Accuracy of Transesophageal Echocardiography for Assessment of Atherosclerosis in the Ascending Aorta in Patients Undergoing Cardiac Surgery

Accurate and Interpretable Computational Modeling of Chemical Mutagenicity

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