Beyond Publication Bias
In drug development, clinical medicine, or health policy making, basing one's decisions on a selective…
CertaraMay 1, 2011
The Development of UGT1A1 and 1A6 in the Pediatric Liver
UDP-glucuronosyltransferases (UGTs) are critical for the metabolism and clearance of drugs, chemicals, and hormones. The…
CertaraMay 1, 2011
Towards a Better Prediction of Peak Concentration, Volume of Distribution, and Half-life After Oral Drug Administration in Man, Using Allometry
It is imperative that new drugs demonstrate adequate pharmacokinetic properties, allowing an optimal safety margin…
CertaraMay 1, 2011
Pharmacokinetics of Clofarabine in Patients with High-risk Inherited Metabolic Disorders Undergoing Brain-sparing Hematopoietic Cell Transplantation
Clofarabine, a newer purine analog with reduced central nervous system toxicity, may prove advantageous in…
CertaraMay 1, 2011
Estimating Toxicity-related Biological Pathway Altering Doses for High-throughput Chemical Risk Assessment
We describe a framework for estimating the human dose at which a chemical significantly alters…
CertaraApril 18, 2011
Pharmacokinetics and Pharmacodynamics of TBR-652, a Novel CCR5 Antagonist, in HIV-1-Infected, Antiretroviral Treatment-experienced and CCR5 Antagonist-naive Patients
TBR-652 is a novel CCR5 antagonist with potent in vitro anti-HIV activity. The objective of…
CertaraApril 12, 2011
In Silico Prediction of Efavirenz and Rifampicin Drug-drug Interaction Considering Weight and CYP2B6 Phenotype
This study aimed to test whether a pharmacokinetic simulation model could extrapolate nonclinical drug data…
CertaraApril 1, 2011
Systematic Review: Diagnostic Accuracy of Clinical Decision Rules for Venous Thromboembolism in Elderly
Physicians committed to the care of elderly patients are challenged with the diagnosis of venous…
CertaraApril 1, 2011
Sources of Interindividual Variability in IVIVE of Clearance: An Investigation into the Prediction of Benzodiazepine Clearance Using a Mechanistic Population-based Pharmacokinetic Model
Prediction of metabolic clearance in extreme individuals rather than the 'average human' is becoming an…
CertaraMarch 24, 2011
Utility of Intersystem Extrapolation Factors in Early Reaction Phenotyping and the Quantitative Extrapolation of Human Liver Microsomal Intrinsic Clearance Using Recombinant Cytochromes P450
Reaction phenotyping using recombinant human cytochromes P450 (P450) has great utility in early discovery. However,…
CertaraMarch 1, 2011
