Systems Pharmacology of the Nerve Growth Factor Pathway: Use of a Systems Biology Model for the Identification of Key Drug Targets Using Sensitivity Analysis and the Integration of Physiology and Pharmacology Publication Systems Pharmacology of the Nerve Growth Factor Pathway: Use of a Systems Biology Model for the Identification of Key Drug Targets Using Sensitivity Analysis and the Integration of Physiology and Pharmacology The nerve growth factor (NGF) pathway is of great interest as a potential source of…CertaraFebruary 21, 2013
Systems Pharmacology for Drug Discovery and Development: Paradigm Shift or Flash in the Pan? Publication Systems Pharmacology for Drug Discovery and Development: Paradigm Shift or Flash in the Pan? Systems pharmacology is an emerging approach that sets out to use quantitative concepts rooted in…CertaraFebruary 20, 2013
Inhibitory Effect of Ketoconazole on the Pharmacokinetics of a Multireceptor Tyrosine Kinase Inhibitor BMS-690514 in Healthy Participants: Assessing the Mechanism of the Interaction with Physiologically-based Pharmacokinetic Simulations Publication Inhibitory Effect of Ketoconazole on the Pharmacokinetics of a Multireceptor Tyrosine Kinase Inhibitor BMS-690514 in Healthy Participants: Assessing the Mechanism of the Interaction with Physiologically-based Pharmacokinetic Simulations BMS-690514, a selective inhibitor of the ErbB and vascular endothelial growth factor receptors, has shown…CertaraFebruary 1, 2013
Bioavailability of Intranasal vs. Rectal Diazepam Publication Bioavailability of Intranasal vs. Rectal Diazepam There remains an unmet medical need in the out-of-hospital management of seizure emergencies because older…CertaraFebruary 1, 2013
Pharmacokinetics, Pharmacodynamics, Physiologically-based Pharmacokinetic Modeling of Monoclonal Antibodies Publication Pharmacokinetics, Pharmacodynamics, Physiologically-based Pharmacokinetic Modeling of Monoclonal Antibodies Development of monoclonal antibodies (mAbs) and their functional derivatives represents a growing segment of the…CertaraFebruary 1, 2013
Analysis of Level A In Vitro-In Vivo Correlations for an Extended-release Formulation with Limited Bioavailability Publication Analysis of Level A In Vitro-In Vivo Correlations for an Extended-release Formulation with Limited Bioavailability A two-stage, numerical deconvolution approach was employed to develop level A in vitro–in vivo correlations…CertaraJanuary 21, 2013
Pharmacometric Approaches to Guide Dose Selection of the Novel GPR40 Agonist TAK-875 in Subjects with Type 2 Diabetes Mellitus Publication Pharmacometric Approaches to Guide Dose Selection of the Novel GPR40 Agonist TAK-875 in Subjects with Type 2 Diabetes Mellitus The G-protein-coupled receptor 40 agonist (GPR40) TAK-875 is being developed as an adjunct to diet…CertaraJanuary 9, 2013
Autoinhibition of CYP3A4 Leads to Important Role of CYP2C8 in Imatinib Metabolism: Variability in CYP2C8 Activity May Alter Plasma Concentrations and Response Publication Autoinhibition of CYP3A4 Leads to Important Role of CYP2C8 in Imatinib Metabolism: Variability in CYP2C8 Activity May Alter Plasma Concentrations and Response Recent data suggest that the role of CYP3A4 in imatinib metabolism is smaller than presumed.…CertaraJanuary 1, 2013
Optimal Sampling Times for a Drug and Its Metabolite Using Simcyp Simulations as Prior Information Publication Optimal Sampling Times for a Drug and Its Metabolite Using Simcyp Simulations as Prior Information Since 2007, it is mandatory for the pharmaceutical companies to submit a Pediatric Investigation Plan…CertaraJanuary 1, 2013
Absolute Abundance and Function of Intestinal Drug Transporters: A Prerequisite for Fully Mechanistic In Vitro-In Vivo Extrapolation of Oral Drug Absorption Publication Absolute Abundance and Function of Intestinal Drug Transporters: A Prerequisite for Fully Mechanistic In Vitro-In Vivo Extrapolation of Oral Drug Absorption The use of whole body physiological-based pharmacokinetic (PBPK) models linked with in vitro-in vivo extrapolation…CertaraJanuary 1, 2013