How Does the In Vivo Biliary Elimination of Drugs Change with Age? Evidence from In Vitro and Clinical Data Using a Systems Pharmacology Approach Publication How Does the In Vivo Biliary Elimination of Drugs Change with Age? Evidence from In Vitro and Clinical Data Using a Systems Pharmacology Approach Information on the developmental changes in biliary excretion (BE) of drugs is sparse. The aims…CertaraJuly 1, 2016
Short-term Efficacy Reliably Predicts Long-term Clinical Benefit in Rheumatoid Arthritis Clinical Trials as Demonstrated by Model-based Meta-analysis Publication Short-term Efficacy Reliably Predicts Long-term Clinical Benefit in Rheumatoid Arthritis Clinical Trials as Demonstrated by Model-based Meta-analysis The objective of this study was to assess the relationship between short-term and long-term treatment…CertaraJuly 1, 2016
Potential Sources of Inter-subject Variability in Monoclonal Antibody Pharmacokinetics Publication Potential Sources of Inter-subject Variability in Monoclonal Antibody Pharmacokinetics Understanding inter-subject variability in drug pharmacokinetics and pharmacodynamics is important to ensure that all patients…CertaraJuly 1, 2016
Considering Age Variation When Coining Drugs as High Versus Low Hepatic Extraction Ratio Publication Considering Age Variation When Coining Drugs as High Versus Low Hepatic Extraction Ratio The hepatic extraction ratio (EH) is commonly considered an "inherent attribute" of drug. It determines…CertaraJuly 1, 2016