Inside the Mind of Pharmacometrics Pioneer, Professor Malcolm Rowland
Officially, Prof. Malcolm Rowland has retired. This scientific pioneer has been helping lay the foundation…
CertaraFebruary 23, 2016
How LC-MS Proteomics Is Revolutionizing PBPK Modeling and Simulation
Drug-metabolizing enzymes and drug transporters play an important role in hepatic drug metabolism and disposition…
CertaraFebruary 18, 2016
How Modeling and Simulation Can Bring New Immuno-oncology Treatments to Patients
Immuno-oncology, which harnesses the patient's own immune system to fight cancer, is one of the…
CertaraFebruary 16, 2016
Conventional & Mechanistic IVIVC: Complementary or Clashing Methods?
An IVIVC (in vitro-in vivo correlation) is a mathematical relationship that predicts key pharmacokinetic parameters…
CertaraFebruary 9, 2016
Impact of Carprofen Administration on Stress and Nociception Responses of Calves to Cautery Dehorning
The objective of this study was to investigate the effects of carprofen administered immediately before…
CertaraFebruary 1, 2016
Incorporating In Vitro Information on Drug Metabolism into Clinical Trial Simulations to Assess the Effect of CYP2D6 Polymorphisms on Pharmacokinetics and Pharmacodynamics: Dextromethorphan as a Model Application
In vitro-in vivo extrapolation of clearance, embedded in a clinical trial simulation, was used to…
CertaraFebruary 1, 2016
