How Can PK/PD Analysis Add Value to Patient Care? Knowledge Base How Can PK/PD Analysis Add Value to Patient Care? In May 2011, T.J. Smith and B.E. Hillner published an opinion piece in the New…CertaraJuly 11, 2011
What is Curve Stripping? Knowledge Base What is Curve Stripping? The process of curve stripping is used in both compartmental and non-compartmental analysis. Each pharmacokinetic…CertaraJuly 6, 2011
Pharmacokinetic-pharmacodynamic Disease Progression Model for Effect of Etanercept in Lewis Rats with Collagen-induced Arthritis Publication Pharmacokinetic-pharmacodynamic Disease Progression Model for Effect of Etanercept in Lewis Rats with Collagen-induced Arthritis The purpose of this study was to develop a pharmacokinetic-pharmacodynamic disease progression (PK/PD/DIS) model to…CertaraJuly 1, 2011
Clinical Tolerance and Toxicity of Intravenous Baclofen: A Pilot Study in a Canine Model Publication Clinical Tolerance and Toxicity of Intravenous Baclofen: A Pilot Study in a Canine Model Assess safety and tolerance of intravenous (IV) baclofen using a dog model. Prospective pharmacokinetic study…CertaraJuly 1, 2011
Simulation of Clinical Drug-drug Interactions from Hepatocyte CYP3A4 Induction Data and Its Potential Utility in Trial Designs Publication Simulation of Clinical Drug-drug Interactions from Hepatocyte CYP3A4 Induction Data and Its Potential Utility in Trial Designs Rifampin and carbamazepine have been recommended in the U.S. Food and Drug Administration draft drug…CertaraJuly 1, 2011
Metabolism of [D10]Phenanthrene to Tetraols in Smokers for Potential Lung Cancer Susceptibility Assessment: Comparison of Oral and Inhalation Routes of Administration Publication Metabolism of [D10]Phenanthrene to Tetraols in Smokers for Potential Lung Cancer Susceptibility Assessment: Comparison of Oral and Inhalation Routes of Administration Polycyclic aromatic hydrocarbons (PAHs) are believed to be among the causative agents for lung cancer…CertaraJuly 1, 2011