PK/PD Modeling & Simulation

Are There Too Many PhDs?

Nathan Teuscher

Elizabeth Weise, a USA Today journalist, posted a story titled “Journals: USA, others need to re-tool their science programs” on April 22, 2011 (link). The premise of the article is that the journal Nature is reporting that there are not enough academic positions available for the number of PhD graduates, and that non-academic industries are […]

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Topics: PK/PD Modeling & Simulation

How to Set Your Target Limit of Quantification

Nathan Teuscher

One of the key things to do during the transition from preclinical development studies to clinical development studies is to set the target for your drug assay limit of quantification (LOQ). I will outline a few considerations on that topic. Here are my main assumptions: You are working with a drug that is intended for […]

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Topics: PK/PD Modeling & Simulation

Calculating AUC (Linear and Log-linear)

Nathan Teuscher

When performing non-compartmental analysis, the area under the concentration-time curve (AUC) is calculated to determine the total drug exposure over a period of time. Together with Cmax, these two parameters are often used to define the systemic exposure of a drug for comparison purposes. For example, in bioequivalence trials, the entire statistical analysis is based […]

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Topics: PK/PD Modeling & Simulation
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