Chemotherapy of Second Stage Human African Trypanosomiasis: Comparison Between the Parenteral Diamidine DB829 and Its Oral Prodrug DB868 in Vervet Monkeys
Human African trypanosomiasis (HAT, sleeping sickness) ranks among the most neglected tropical diseases based on…
CertaraFebruary 15, 2015
Calculating the Elimination Rate Constant
The elimination rate constant is the rate at which drug is cleared from the body…
CertaraFebruary 2, 2015
Population Pharmacokinetics of Ceftolozane/Tazobactam in Healthy Volunteers, Subjects with Varying Degrees of Renal Function and Patients with Bacterial Infections
Ceftolozane/tazobactam is a novel antipseudomonal cephalosporin and a β-lactamase inhibitor in clinical development for treatment…
CertaraFebruary 1, 2015
Common Misconceptions About Computer System Validation
January 28, 2015 Drug development professionals frequently use computer systems to help them understand the…
CertaraJanuary 28, 2015
Using Modeling and Simulation to Quantify the PK of an Anti-HIV Drug for Babies
As a scientist at Certara and proud Dad to my three kids, pediatric drug development…
CertaraJanuary 15, 2015
Prediction of the Pharmacokinetics, Pharmacodynamics, and Efficacy of a Monoclonal Antibody, Using a Physiologically-based Pharmacokinetic FcRn Model
Although advantages of physiologically based pharmacokinetic models (PBPK) are now well established, PBPK models that are linked to pharmacodynamic…
CertaraJanuary 5, 2015
Mechanistic Models Describing Active Renal Reabsorption and Secretion: A Simulation-based Study
The objective of the present study was to evaluate mechanistic pharmacokinetic models describing active renal secretion and reabsorption over a range of Michaelis-Menten parameter estimates and doses.…
CertaraJanuary 1, 2015
Study Reanalysis Using a Mechanism-based Pharmacokinetic/Pharmacodynamic Model of Pramlintide in Subjects with Type 1 Diabetes
This report describes a pharmacokinetic/pharmacodynamic model for pramlintide, an amylinomimetic, in type 1 diabetes mellitus…
CertaraJanuary 1, 2015
The Effect of Plasmapheresis on Blood Pressure in Voluntary Plasma Donors
Donor plasmapheresis involves the removal of a weight-adjusted volume of plasma and the return of…
CertaraJanuary 1, 2015
