The Antibody-Drug Conjugate (ADC) Model Pack delivers a ready-to-use library of 42 QSP models covering monospecific and bispecific ADCs, enabling faster, more confident decision-making across discovery and development.
QSP MODELS
Pre-built Quantitative Systems Pharmacology Models for Antibody-Drug Conjugates
Optimize ADC development with validated, mechanistic QSP models designed for complex biotherapeutics
Why QSP Modeling for Antibody-Drug Conjugates?
Antibody-drug conjugates are among the most complex therapeutic modalities, combining targeting antibodies, cytotoxic payloads, and linker chemistry into a single system. Their development is challenged by:
- Narrow therapeutic windows
- Complex PK/PD relationships
- Intracellular payload release dynamics
- Translational uncertainty from preclinical to clinical
QSP models provide a mechanistic framework to simulate these dynamics and predict outcomes, improving dose selection, efficacy, and safety.
What’s Included in the ADC Model Pack?
Comprehensive QSP Model Library
- 42 validated QSP models for:
- Monospecific and bispecific ADCs
- Avidity and non-avidity systems
- Multi-compartment pharmacokinetics
- Mechanistic representation of:
- Target binding (membrane ligands)
- Payload release and intracellular processing
- Tumor and systemic exposure
Built for Real-World ADC Development
- Supports in vitro → in vivo → clinical translation
- Includes:
- Mechanism-of-action diagrams
- Parameterized models with literature-backed values
- Designed for rapid simulation and hypothesis testing
What You Can Achieve
With the ADC Model Pack, you can:
- Optimize first-in-human dose selection
- Predict efficacy and toxicity outcomes
- Explore drug-antibody ratio (DAR) impacts
- Simulate tumor penetration and payload delivery
- Reduce development risk with model-informed decisions
Powered by Best-in-Class QSP Software, Certara IQ™
Run and customize models using Certara IQ™, an AI-enabled QSP software that:
- Enables fast, collaborative model development
- Provides pre-validated model libraries
- Supports cloud-based simulation and analysis
- Ensures regulatory-ready workflows and reporting
Download the QSP models
Simply fill out the form and download the Antibody-Drug Conjugate (ADC) Model Pack.
About Certara
Certara is dedicated to transforming drug discovery and development for good. We harness the power of biosimulation, advanced analytics, and regulatory expertise to create a future where treatments reach patients faster and more efficiently.
From discovery to market access and commercial, we tailor solutions to meet our clients’ most pressing challenges. Through strategic leadership and advanced predictive technologies, Certara provides comprehensive solutions to optimize drug development processes, reduce risks, and improve outcomes. Our clients include more than 2,400 biopharmaceutical companies, academic institutions, and regulatory agencies across 70 countries.
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