The Use of Model-informed Precision Dosing to Improve Patient Drug Treatment Outcomes

Precision dosing—delivering the right dose, of the right drug, to the right patient, at the right time—is a crucial cornerstone of precision medicine that will provide patients with the most efficacious medications with minimum probability of adverse events. Model-informed precision dosing, using quantitative mechanistic modeling and simulation tools, such as PBPK and NLME, can improve patient outcomes by maximizing therapeutic benefit and reduce risk.