Using Modeling and Simulation to Optimize Dosing of an Anti-infective for Children

Pediatric drug development can, in many ways, be described as a “Catch 22.” It is extremely challenging (both logistically and ethically) to enroll children in clinical trials, yet without a proper and approved clinical process, physicians are left with inaccurate dosing and therapeutic approaches for children. Modeling and simulation methods, including population PK modeling, are reshaping the pharmaceutical industry’s approach to pediatric drug development. In this webinar, Dr. Nathalie Gosselin presented a case study wherein Certara Strategic Consulting scientists leveraged population PK modeling and simulation to help optimize dosing of an antibiotic for infants.