Watch this webinar with C-Path’s Dr. Klaus Romero to learn how they integrated these components into the latest version of the Simcyp Simulator to establish a robust resource that will help development teams and regulators evaluate the safety and efficacy of novel anti-TB drug regimens.Read More
Tuberculosis (TB)—caused by infection with the mycobacterium Mycobacterium tuberculosis—is one of the top 10 leading causes of death worldwide with a total of 1.8 million people dying from the disease in 2015. TB is also the leading cause of death in HIV-infected individuals. TB usually attacks the lungs but can infect any part of the […]Read More
The Critical Path to TB Drug Regimens Initiative partnered with Certara to develop a population-based lung model that mimics drug disposition at different stages of tuberculosis infection.Read More
What would you guess is the world’s most neglected disease? I bet that you wouldn’t pick tuberculosis (TB)— a disease that causes an estimated 9 million new cases and 1.3 million deaths annually. This infectious disease is caused by the bacterium Mycobacterium tuberculosis. TB usually attacks the lungs, but can attack any part of the body.
Patients infected with TB are typically treated with a standard six-month course of multiple antimicrobial drugs. It is quite difficult to get patients to adhere to this long course of treatment. Often, patients will fail to complete the entire drug course. This increases the likelihood of relapse and antibiotic resistance developing. Thus, there is an urgent need for shorter treatment regimens that minimize the risk of relapse. In this blog post, I’ll discuss how meta-regression modeling of relapse can inform TB clinical trial design.Read More