PBPK Modeling & Simulation

New Tools Support Developing Better TB Drugs

I. Gardner & O. Hatley

Tuberculosis (TB)—caused by infection with the mycobacterium Mycobacterium tuberculosis—is one of the top 10 leading causes of death worldwide with a total of 1.8 million people dying from the disease in 2015. TB is also the leading cause of death in HIV-infected individuals. TB usually attacks the lungs but can infect any part of the […]

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Topics: PBPK Modeling & Simulation

SIVA Toolkit V2: Simcyp In Vitro Analysis Toolkit

The SIVA Toolkit is a user-friendly platform, specifically designed to assist scientists with the analysis of complex in vitro studies using whole cells, tissue samples and solid dosage forms to assess the metabolism, transport and dissolution/solubility of drugs. SIVA combines the latest model-based data analysis approaches with powerful optimization algorithms in a sophisticated statistical environment.

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Simcyp In Vitro Analysis (SIVA) Toolkit: Get the Most from Your In Vitro Data

Analysis of in vitro data from whole cell systems and dissolution studies is complex, challenging and time consuming. Yet accurate data analysis and informed data interpretation early in drug development is crucial. Existing tools have mainly been developed for broader data analysis and are not specifically designed for in vitro systems. These software tools do not readily support analysis […]

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Analyzing Complex In Vitro Experiments: It’s Not as Hard as You Think

Krishna Machavaram

Analyzing in vitro experiments can be challenging and time consuming. Yet, crucial decisions depend on accurate data analysis and interpretation early in development. Unfortunately, most lab-based scientists lack access to state-of-the-art models for analyzing in vitro data. A new tool enables the analysis of data generated from complexin vitro studies. These studies include assays using […]

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Topics: Model-based Meta-analysis, PK/PD Modeling & Simulation
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