The Model-informed Precision Dosing Revolution Is Coming

Suzanne Minton

Modeling and simulation (M&S) has been widely accepted and adopted by biopharmaceutical companies and global regulatory agencies. However, its implementation in clinical care has been modest to date. Model-based approaches are essential to realize the goal of precision dosing—providing the right drug dose to maximize therapeutic benefit, while reducing risk for each individual patient. The […]

Read More
Topics: PBPK Modeling & Simulation, PK/PD Modeling & Simulation

What You Need to Know about the Precision Medicine Initiative

Suzanne Minton

Last month, I was fortunate to be able to represent Certara at the BIO International Conference in Philadelphia, PA. One of the most exciting sessions that I attended was the Personalized Medicine Plenary with Dr. Francis Collins, the director of the NIH. He discussed how the Precision Medicine Initiative (PMI) will revolutionize the approach to […]

Read More
Topics: Clinical Transparency & Disclosure

Why Do We Customize Aminoglycoside Dosing?

Nathan Teuscher

Aminoglycosides are a class of molecules that are used for the treatment of serious gram-negative systemic infections. Some common aminoglycosides are tobramycin, gentamicin, amikacin, and neomycin. Aminoglycosides have bactericidal activity against most gram-negative bacteria including Acinetobacter, Citrobacter, Enterobacter, E. Coli, Klebsiella, Proteus, Providencia, Pseudomanas, Salmonella, Serratia and Shigella. Aminoglycosides are also active against most strains of Staphylococcus aureus and S. epidermidis. Most strains […]

Read More
Topics: PK/PD Modeling & Simulation

How Can PK/PD Analysis Add Value to Patient Care?

Nathan Teuscher

In May 2011, T.J. Smith and B.E. Hillner published an opinion piece in the New England Journal of Medicine titled “Bending the Cost Curve in Cancer Care” (link). In this opinion piece, Smith and Hillner suggest that the rapidly increasing cost of treating cancer is not sustainable. “We must find ways to reduce the costs […]

Read More
Topics: PK/PD Modeling & Simulation
Learn More
LinkedIn