PK/PD Modeling & Simulation

Derivation for Logarithmic Trapezoidal AUC Calculation

Nathan Teuscher

Calculating area under the curve requires the use of two separate equations: one is follows the “linear trapezoidal rule” and the other follows the “logarithmic trapezoidal rule.” These equations are normally presented in textbooks without derivations so all you have to do is insert the concentrations and times and you can calculate the area under […]

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Topics: PK/PD Modeling & Simulation

Calculating AUC (Linear and Log-linear)

Nathan Teuscher

When performing non-compartmental analysis, the area under the concentration-time curve (AUC) is calculated to determine the total drug exposure over a period of time. Together with Cmax, these two parameters are often used to define the systemic exposure of a drug for comparison purposes. For example, in bioequivalence trials, the entire statistical analysis is based […]

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Topics: PK/PD Modeling & Simulation
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