Using Sampling “Windows” for PK Blood Samples

Nathan Teuscher

One of the most common questions posed by clinical operations experts when including pharmacokinetic sampling in a clinical trial is the following: “What is the time window we should allow for each blood sample?” My answer is always the same: “Don’t include any window.” I am almost always met with a confused look. The confusion is […]

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Topics: PK/PD Modeling & Simulation

What is a Loading Dose?

Nathan Teuscher

Drug therapy in chronic disease situations requires systemic drug levels to reach target steady-state levels for maximum safety and efficacy. The time it takes for a drug to reach steady-state is a function of the elimination half-life of the drug. The following table illustrates how long it will take to achieve steady-state relative to the […]

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Topics: PK/PD Modeling & Simulation
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