This webinar addressed some of the challenges associated with pediatric drug development and the advantages (and limitations) that pediatric population PK modeling can provide.
Read MoreTag: Allometric Scaling
Phoenix Modeling Language School
Learn How to Build Custom PK and PK/PD Models Phoenix WinNonlin™ uses Phoenix Modeling Language (PML) to encode pharmacokinetic (PK) and Pharmacodynamic (PD) models. Although most models can be built using the graphical user interface (GUI) in Phoenix, there are some models that require custom coding with PML. Certara has launched a series of interactive educational […]
Read MoreAutomated Prediction of First-in-man Dosing Using Pre-clinical PK Data
Humans differ from commonly used pre-clinical model organisms (rats, dogs, monkeys) in terms of their biochemistry, physiology, and anatomy. Predicting a drug’s pharmacokinetic (PK) profile in humans using animal PK data must account for these differences. Allometric scaling is used to predict human PK parameters based on animal data. While allometric scaling has been used […]
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