Automated Prediction of First-in-man Dosing Using Pre-clinical PK Data

Humans differ from commonly used pre-clinical model organisms (rats, dogs, monkeys) in terms of their biochemistry, physiology, and anatomy. Predicting a drug’s pharmacokinetic (PK) profile in humans using animal PK data must account for these differences. Allometric scaling is used to predict human PK parameters based on animal data. While allometric scaling has been used […]

Read More
Topics:
Learn More LinkedIn Twitter Facebook Email Subscribe to the Blog