Prediction of Midazolam Concentration Profile in Obese Adolescent Population Using Physiologically Based Pharmacokinetic model
0 comments.
Click here to read/write comments.
Topics:
Tag: Age
Considering Age Variation When Coining Drugs as High Versus Low Hepatic Extraction Ratio
The hepatic extraction ratio (EH) is commonly considered an “inherent attribute” of drug. It determines the main physiological and biological elements of the system (patient attributes) that are most significant in interindividual variability of clearance. The EH consists of three age-dependent parameters: fraction of unbound drug in blood (fu.B), hepatic intrinsic clearance of unbound drug […]
Read More
0 comments.
Click here to read/write comments.
Topics: