Prediction of Drug-drug Interactions

Prediction of Drug-drug Interactions

Predicting Drug-drug Interactions Using the Simcyp Simulator Unmanageable drug-drug interactions have led to the withdrawal of numerous drugs from the market. Many of these interactions involve inhibition and, to a lesser extent, induction of drug metabolizing enzymes. Consequently, the ability to predict metabolically-based drug-drug interactions (mDDI) early in the drug development process is essential. The sophisticated […]

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Prediction of Clearance

Predicting Drug Clearance Using the Simcyp Simulator The Simcyp® Simulator predicts in vivo drug clearance from in vitro data, for the average individual and across populations. It also measures variability in clearance as a function of: Proportional metabolism by each enzyme Genetic/environmental variations in enzyme abundance Ethnic differences in genotype frequencies and levels of CYP and UGT […]

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Drug Metabolism

Assessing Drug Metabolism Using the Simcyp Simulator The Simcyp® Simulator extrapolates in vivo metabolic clearance from routine in vitro data generated during drug development using a variety of systems, including human liver microsomes (HLM), human intestinal microsomes (HIM), human hepatocytes (HHEP), recombinant cytochrome P450 and UGT enzymes (rCYP, rUGT), and cytosolic or S9 tissue fractions. […]

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Distribution

Predicting Drug Distribution Characteristics Using the Simcyp Simulator The Simcyp® Simulator allows the prediction of drug distribution characteristics at several levels, including Prediction of Vss from drug lipophilicity and plasma protein binding data Prediction of drug concentration-time profiles in blood and tissues based on a full physiologically-based pharmacokinetic (PBPK) model The Simcyp Simulator estimates the variability in […]

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Absorption

Simulating Drug Absorption Using the Simcyp Simulator The Simcyp® Simulator’s models allows simulation of absorption through oral, dermal, and pulmonary routes. Oral absorption Oral delivery is the preferred route of administration for most drugs. Therefore, in the preclinical phase of development, a key consideration for many new chemical entities is their rate and extent of intestinal […]

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