Achieving a pathway-based approach to more efficient chemical risk assessment.
Read MoreThe Emergence of Quantitative Systems Toxicology
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Solutiuon: PBPK Modeling & Simulation
Using Model Reduction to Bridge the QSP-Pharmacometrics Divide
In this webinar, Dr. Tom Snowden demonstrated: why reduction methods are a potent and necessary tool in the modeler’s arsenal; how reduction methods can be applied to QSP models; and, how model reduction can be used to extract scientific and business insights from complex models.
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How to Pick the Right Drug Doses for Pregnant Women
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Professor Jennifer Dressman Joins Certara’s Simcyp Scientific Advisory Board
PRINCETON, NJ – July 13, 2017 – Certara today announced that Professor Jennifer B. Dressman, PhD, has been appointed to the Simcyp Scientific Advisory Board (SAB) to further strengthen its status in the biopharmaceutics field.
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Using Modeling and Simulation to Combat Tuberculosis: A Global Health Priority
Watch this webinar with C-Path’s Dr. Klaus Romero to learn how they integrated these components into the latest version of the Simcyp Simulator to establish a robust resource that will help development teams and regulators evaluate the safety and efficacy of novel anti-TB drug regimens.
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Mechanistic Modeling of Genome Scale Molecular Interaction Networks
Upon the completion of the Human Genome Project, the lead investigator, Dr. Francis Collins remarked: Science is a voyage of exploration into the unknown. We are here today to celebrate a milestone along a truly unprecedented voyage, this one into ourselves. Alexander Pope wrote, “Know then thyself. Presume not God to scan. The proper study […]
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PBPK Modeling & Simulation, Systems PharmacologyApplication of Physiologically-based Pharmacokinetic Model to Predict Tramadol Concentration in Human Milk
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Prediction of the Pharmacokinetics of Renally-excreted Antiretrovirals in Older Patients, Using Physiologically-based Pharmacokinetic (PBPK) Modeling
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Simulation of Pharmacokinetics of Amitriptyline and Nortriptyline and Their Common Effect on Human Cardiac Electrophysiology in Healthy Population
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Physiologically-based Pharmacokinetic Model (PBPK) for the Halofantrine Cardiac Effect Prediction – Proof of Concept Study towards the System for the Antimalarial Drugs Cardiac Safety Assessment
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Predicting Human Fetal Exposure using Physiologically-based Pharmacokinetic Models
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Sensitivity Analysis of P-glycoprotein Ki Values in Dynamic DDI Predictions
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Statistical Power Analysis to Detect Drug-drug Interaction between Lorezapam and Probenecid in Healthy and Renal-impaired Populations Using PBPK Modeling and the Simcyp R Package
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Accuracy of Plasma Clearance Scaling from Adults to Children Using Pathway-specific Covariate Models: A Systematic Investigation Using a Physiologically-based Pharmacokinetic Workflow
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Application of Global Sensitivity Analysis Methods to Determine the Most Influential Parameters of a Minimal PBPK Model of Quinidine
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Certara Launches CODEx to Inform Comparative Effectiveness and Drug Development Decisions
PRINCETON, NJ – June 6, 2017 – Certara today launched its Clinical Outcomes Database Explorer (CODEx). An intuitive, web-based platform, CODEx enables drug development teams to easily visualize, explore, analyze and communicate content from Certara’s Clinical Trial Outcomes Databases and assess a given compound’s probability of success against competitor drugs.
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Predicting Diclofenac Systemic and Synovial Fluid Concentrations After Dermal Application Using the Multi-phase Multi-layer MechDermA PBPK Model
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Virtual Bioequivalence Assessment of Two Tramadol Formulations Using the Advanced Dissolution Absorption and Metabolism (ADAM) Model via Simcyp R Package
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A Whole Body Physiologically-based Pharmacokinetic Model for Antibody Drug Conjugates – Model Development and Validation in Rat
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Nurturing the Pharmacometricians of the Future
As a scientist, you always remember your first conference. The ability to share your research and learn from your peers is an invaluable part of any scientist’s training. That’s why I’m so proud that Certara helps support the travel and accommodation expenses for a selected number of students wishing to attend the Population Approach Group […]
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PBPK Modeling & Simulation, PK/PD Modeling & Simulation