PK/PD Modeling and Simulation

Phoenix: The Most Advanced, Intuitive, and Widely-used Software for Pharmacokinetic (PK), Pharmacodynamic (PD), and Toxicokinetic (TK) Modeling and Simulation

Phoenix®, the industry’s premier PK/PD modeling and simulation software workbench, is used by over 6,000 scientists in 60 countries at nearly 2,000 institutions, including the top 50 global pharmaceutical companies. Regulatory agencies, including 11 divisions of the US Food and Drug Administration (FDA), Japan Pharmaceutical and Medical Device Agency (PMDA), China Food and Drug Administration (CFDA), and the UK Medicines and Healthcare Products Regulatory Agency (MHRA), use Phoenix for analysis and to evaluate drug submissions.

Intuitive and user-friendly experience

Phoenix is based on the concept of using graphical workflows to guide users in visualizing data flow and analysis pathways. Specific objects are used for each action, such as data processing, table creation, creating figures and plots, performing modeling and simulation, and reporting results. These workflows, unique to Phoenix, can be saved, customized, reused, and shared to deliver reproducibly quality data in the most efficient way possible. Since all products in Phoenix share the same intuitive GUI, users can seamlessly move between products, from performing NCA into more complex PK/PD.

Powerful modeling engines

Phoenix WinNonlin® is the preeminent tool for NCA analysis, leveraging the most sophisticated modeling engine. Phoenix NLME™ includes a full suite of algorithms for non-linear mixed effects models including QRPEM, the most advanced expectation maximization algorithm available anywhere. Integrated support for parameter estimation, simulation, automated covariate searches, bootstrap parameter estimation, and visual predictive checks give a user the flexibility to conduct all phases of a PK/PD analysis with a single intuitive tool.

An interoperable pharmacometric workbench

The Phoenix workbench contains all the tools you need in a single, interoperable platform. Pre-clinical and clinical knowledge can be easily shared throughout an organization and a drug can be tracked through the development lifecycle via a secure and consistent workflow using our integrated Phoenix-based tools and 3rd-party applications.

We’re committed to your success

We provide a wide range of education and support tools to get you started and to keep you up-to-date with the most important advancements in modeling, including step-by-step guides, classroom and on-demand e-learning training courses available through Certara University, webinars, educational blog posts and access to an active user support forum community.

Contact us to learn why Phoenix WinNonlin is the trusted, long time industry standard software tool for PK/PD modeling, non-compartmental and compartmental analysis.

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