Model-informed Drug Development
Incorporating population variability into mechanistic prediction of PK and modeling PK/PD
November 26–30 in Shanghai, China
Delegates will learn how to simulate:
- Metabolic drug clearance (CL)
- Metabolic drug-drug interactions (DDIs)
- Gut first-pass metabolism
- Oral drug absorption incorporating food effects and the impact of dosage form
- Effect of transporters and enterohepatic recirculation on kinetics and DDIs
- Drug distribution to different organs
- Population variability in drug concentration-time profiles
- Variation in kinetics in specific populations (pediatrics, ethnic groups, various disease populations)
- Data for therapeutic proteins
- Pharmacodynamic effects of different compounds
- Time-course of drug in plasma that fits observed clinical data (achieved by combining fitting techniques with IVIVE, PBPK and drug specific in vitro data)
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