Kinetic Values for Mechanism-based Enzyme Inhibition: Assessing the Bias Introduced by the Conventional Experimental Protocol

Author(s): Jiansong Yang, Masoud Jamei. Karen Rowland Yeo, Geoffrey Tucker, Amin Rostami-Hodjegan
Year: November 1, 2005

Changes in Liver Volume from Birth to Adulthood: A Meta-analysis

Author(s): Trevor Johnson, Geoffrey Tucker, M. Stuart Tanner, Amin Rostami-Hodjegan
Year: December 1, 2005

Enriched Analgesic Efficacy Studies: An Assessment by Clinical Trial Simulation

Author(s): Hendrikus Lemmens, Russell Wada, Catherine Munera, Ahmed Eltahtawy, Donald Stanski
Year: April 1, 2006

Development of a Predictive Pharmacokinetic Model for a Novel Cyclooxygenase-2 Inhibitor

Author(s): Helen Kastrissios, Shashank Rohatagi, James Moberly, Kenneth Truitt, Christine Yuying Gao, Russell Wada, Mao Takahashi, Kunitada Kawabata, Daniel Salazar
Year: May 1, 2006

Prediction of In Vivo Drug Clearance from In Vitro Data, I: Impact of Inter-individual Variability

Author(s): Eleanor Howgate , Karen Rowland Yeo, Nicholas Proctor, Geoffrey Tucker, Amin Rostami-Hodjegan
Year: June 1, 2006

Prediction of In Vivo Drug Clearance from In Vitro Data, II: Potential Inter-ethnic Differences

Author(s): Shintaro Inoue, Eleanor Howgate, Hideya Yamazaki,Tsutomu Shimada, Karen Rowland Yeo, Geoffrey Tucker, Amin Rostami-Hodjegan
Year: June 1, 2006

Prediction of Metabolic Drug Clearance in Humans: In Vitro-In Vivo Extrapolation vs Allometric Scaling

Author(s): Mohammad Reza Shiran, Nicholas Proctor, Eleanor Howgate, Karen Rowland Yeo, Geoffrey Tucker, Amin Rostami-Hodjegan
Year: July 1, 2006

Prediction of Clearance of Eleven Drugs and Associated Variability in Neonates

Author(s): Trevor Johnson, Geoffrey Tucker, Amin Rostami-Hodjegan
Year: September 1, 2006

Implications of Mechanism-based Inhibition of CYP2D6 for the Pharmacokinetics and Toxicity of MDMA

Author(s): Jiansong Yang, Masoud Jamei, Amir Heydari, Karen Rowland Yeo, Rafael de la Torre, Magí Farré, Geoffrey Tucker, Amin Rostami-Hodjegan
Year: November 1, 2006

The Impact of Experimental Design on Assessing Mechanism-based Inactivation of CYP2D6 by MDMA (Ecstasy)

Author(s): Linh Van, Jiansong Yang, Martin Lennard, Amir Heydari, Karen Rowland Yeo, Jonathan Hargreaves, Geoffrey Tucker, Amin Rostami-Hodjegan
Year: November 1, 2006

Scaling Factors for the Extrapolation of In Vivo Metabolic Drug Clearance from In Vitro Data: Reaching a Consensus on Values of Human Microsomal Protein and Hepatocellularity per Gram of Liver

Author(s): David Carlile, Alan Boobis, Amin Rostami-Hodjegan, Brian Lake, Geoffrey Tucker, J. Brian Houston, John Lipscomb, Martin Bayliss, Olavi Pelkonen, Philip Beaune, Robert Edwards, Zoe Barter
Year: January 1, 2007

Simulation and Prediction of In Vivo Drug Metabolism in Human Populations from In Vitro Data

Author(s): Amin Rostami-Hodjegan, Geoffrey Tucker
Year: February 1, 2007

Predictive Population Pharmacokinetic/Pharmacodynamic Model for a Novel COX-2 Inhibitor

Author(s): Shashank Rohatagi, Helen Kastrissios, Christine Yuying Gao, Nancy Zhang, J. Xu, James Moberly, Russell Wada, Kazutaka Yoshihara, Mao Takahashi, Kenneth Truitt, Daniel Salazar
Year: March 1, 2007

Misuse of the Well-stirred Model of Hepatic Drug Clearance

Author(s): Jiansong Yang, Masoud Jamei, Karen Rowland Yeo, Amin Rostami-Hodjegan, Geoffrey Tucker
Year: March 1, 2007

The Problems in Scaling Adult Drug Doses to Children

Author(s): Trevor Johnson
Year: March 15, 2007

Kinetics of the Time-dependent Inactivation of CYP2D6 in Cryopreserved Human Hepatocytes by Methylenedioxymethamphetamine (MDMA)

Author(s): Linh Van, John Swales, Clare Hammond, Claire Wilson, Judith Hargreaves, Amin Rostami-Hodjegan
Year: May 1, 2007

Theoretical Assessment of a New Experimental Protocol for Determining Kinetic Values Describing Mechanism (time)-based Enzyme Inhibition

Author(s): Jiansong Yang, Masoud Jamei, Karen Rowland Yeo, Geoffrey Tucker, Amin Rostami-Hodjegan
Year: July 1, 2007

The Use of Mechanistic DM-PK-PD Modeling to Assess the Power of Pharmacogenetic Studies—CYP2C9 and Warfarin as an Example

Author(s): Gemma Dickinson, Martin Lennard, Geoffrey Tucker, Amin Rostami-Hodjegan
Year: July 1, 2007

Inactivation of CYP2D6 by Methylenedioxymethamphetamine in Different Recombinant Expression Systems

Author(s): Linh Van, Judith Hargreaves, Martin Lennard, Geoffrey Tucker, Amin Rostami-Hodjegan
Year: September 1, 2007

Modeling, Simulation, and the Critical Path

Author(s): Daniel Weiner
Year: September 6, 2007