Caffeine Metabolic Ratios as Markers of Enzyme Activity: A Theoretical Assessment

Author(s): Amin Rostami-Hodjegan, Samuli Nurminen, Peter Jackson, Geoffrey Tucker
Year: April 1, 1996

The Determination of Drug Metabolizing Enzyme Activity In Vivo: Pharmacokinetics and Statistical Issues

Author(s): Geoffrey Tucker, Amin Rostami-Hodjegan, Peter Jackson
Year: December 1, 1998

In Vivo Indices of Enzyme Activity—The Effect of Renal Impairment on the Assessment of CYP2D6 Activity

Author(s): Amin Rostami-Hodjegan, Heyo Kroemer, Geoffrey Tucker
Year: June 1, 1999

A Population Pharmacokinetic/Pharmacodynamic Analysis of Repeated Measures Time-to-event Pharmacodynamic Responses: The Antiemetic Effect of Ondansetron

Author(s): Eugène Cox, Christine Veyrat-Follet, Stuart Beal, Eliane Fuseau, Sonya Kenkare, Lewis Sheiner
Year: December 1, 1999

Combining Drug-disease and Economic Modeling to Inform Drug Development Decisions

Author(s): Bill Poland, Russell Wada
Year: November 1, 2001

Pharmacokinetics of Melagatran and the Effect on Ex Vivo Coagulation Time in Orthopedic Surgery Patients Receiving Subcutaneous Melagatran and Oral Ximelagatran: A Population Model Analysis

Author(s): Ulf Eriksson, Jaap Mandema, Mats Karlsson, Lars Frison, Per Olsson Gisleskog, Ulrika Wählby, Bengt Hamrén, David Gustafsson, Bengt Eriksson
Year: January 1, 2003

The Effects of Dose Staggering on Metabolic Drug-drug Interactions

Author(s): Jiansong Yang, Maria Kjellsson, Amin Rostami-Hodjegan, Geoffrey Tucker
Year: October 1, 2003

The Use of Clinical Trial Simulation to Support Dose Selection: Application to Development of a New Treatment for Chronic Neuropathic Pain

Author(s): Park Lockwood, Jack Cook, Wayne Ewy, Jaap Mandema
Year: November 1, 2003

Prediction of Clearance from Recombinantly Expressed CYPs: Intersystem Extrapolation Factor (ISEF)

Author(s): Nicholas Proctor, Geoffrey Tucker, Amin Rostami-Hodjegan
Year: February 1, 2004

Pharmacogenetics—Expectations and Reality

Author(s): Geoffrey Tucker
Year: July 1, 2004

Cytochrome P450 3A Expression and Activity in the Human Small Intestine

Author(s): Jiansong Yang, Geoffrey Tucker, Amin Rostami-Hodjegan
Year: October 1, 2004

In Silico Simulations to Assess the In Vivo Consequences of In Vitro Metabolic Drug-drug Interactions

Author(s): Amin Rostami-Hodjegan, Geoffrey Tucker
Year: December 1, 2004

Assessment of In Vivo CYP2D6 Activity: Differential Sensitivity of Commonly Used Probes to Urine pH

Author(s): Mahmut Ozdemir, Kim Crewe, Geoffrey Tucker, Amin Rostami-Hodjegan
Year: December 1, 2004

Predicting the Clearance of CYP2C9 Substrates

Author(s): Karen Rowland Yeo, Eleanor Howgate, Geoffrey Tucker, Amin Rostami-Hodjegan
Year: December 1, 2004

Population Pharmacokinetics of Olmesartan Following Oral Administration of Its Prodrug, Olmesartan Medoxomil: In Healthy Volunteers and Hypertensive Patients

Author(s): Kazutaka Yoshihara, Christine Yuying Gao, Masafumi Hisaoka, Hiroshi Shiga, Russell Wada
Year: January 1, 2005

Does Neuromuscular Electrical Stimulation Strengthen the Quadriceps Femoris? A Systematic Review of Randomized Controlled Trials

Author(s): Leon Bax, Filip Staes, Arianne Verhagen
Year: January 1, 2005

Modelling Approaches to Dose Estimation in Children

Author(s): Trevor Johnson
Year: June 1, 2005

Therapeutic Benefit of Eletriptan Compared to Sumatriptan for the Acute Relief of Migraine Pain—Results of a Model-based Meta-analysis that Accounts for Encapsulation

Author(s): Jaap Mandema, Eleanor Cox, Jess Alderman
Year: September 1, 2005

Model-based Covariate Pharmacokinetic Analysis and Lack of Cortisol Suppression by the New Inhaled Corticosteroid Ciclesonide Using a Novel Cortisol Release Model

Author(s): Shashank Rohatagi, Sriram Krishnaswami, Srikumar Sahasranaman, Marc Pfister
Year: September 1, 2005

Model-based Development of Gemcabene, a New Lipid-altering Agent

Author(s): Jaap Mandema, David Hermann, Wenping Wang, Tim Sheiner, Mark Milad, Rebecca Bakker-Arkema, Daniel Hartman
Year: October 7, 2005