Quantitative Structure–property Relationships of Camptothecins in Humans

The purpose of this study was to develop quantitative structure property relationships (QSPR) for the pharmacokinetics and the susceptibility to BCRP-mediated efflux of ten drugs in the camptothecin family of topoisomerase I inhibitors.
Pharmacokinetic parameters (total and lactone clearance, total steady-state volume of distribution, and lactone:total area under the curve ratio) and IC50 values of cytotoxicity in both BCRP over-expressing and sensitive cell lines were extracted from the literature.
 

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