Novel Analogs of Istaroxime, a Potent Inhibitor of Na(+),K(+)-ATPase: Synthesis, Structure-activity Relationship, and 3D-quantitative Structure-activity Relationship of Derivatives at Position 6 on the Androstane Scaffold

We report the synthesis and biological properties of novel analogues of Istaroxime acting as positive inotropic compounds through the inhibition of the Na(+),K(+)-ATPase. We explored the chemical space around the position 6 of the steroidalscaffold by changing the functional groups at that position and maintaining a basic oximic chain in position 3.

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