Bias in Estimates of Metabolic Constants When Applying the Michaelis-Menten Equation to Drugs Exhibiting Atypical Enzyme Kinetics

Author(s): M. Jamei, A. L. Finnoy, G. T. Tucker, A. Rostami-Hodjegan
Year:

Theoretical Assessment of a New Experimental Protocol for Determining Kinetic Values Describing Mechanism (Time)-based Enzyme Inhibition

Author(s): J. Yang, M. Jamei, K. Rowland-Yeo, G. T. Tucker, A. Rostami-Hodjegan
Year:

Prediction of In Vivo Drug Interactions from In Vitro Enzyme Kinetic Data: Time-based Versus Steady State Simulations

Author(s): K. Rowland-Yeo, M. Jamei, J. Yang, G. T. Tucker, A. Rostami-Hodjegan
Year:

The Impact of Genetic Polymorphism in CYP3A5 on the Pharmacokinetics of the Mixed 3A4/5 Substrates Midazolam and Tacrolimus Assessed by Clinical Trial Simulation (CTS)

Author(s): H. F. Perrett, Z. E. Barter, M. S. Lennard, G. T. Tucker, A. Rostami-Hodjegan
Year:

Assessing the Relevance of Genetic Polymorphism in CYP3A5 on the Kinetics of Midazolam and Tacrolimus: The Importance of Adequate Study Size

Author(s): H. F. Perrett, Z. E. Barter, M. S. Lennard, G. T. Tucker, A. Rostami-Hodjegan
Year:

A Novel Physiologically-based Mechanistic Model for Predicting Oral Drug Absorption: The Advanced Dissolution, Absorption, and Metabolism (ADAM) Model

Author(s): M. Jamei, J. Yang, D. Turner, K. R. Yeo, G. T. Tucker, A. Rostami-Hodjegan
Year:

Experimental Considerations in Determining Inter System Extrapolation Factors Required for Prediction of Human Drug Clearance from Recombinantly Expressed Enzymes

Author(s): Z. E. Barter, K. H. Crewe, K. Rowland-Yeo, G. T. Tucker, A. Rostami-Hodjegan
Year:

Impact of Variability in Estimates of Drug Diffusion Coefficient on the Prediction of Fraction Absorbed from the Gut (fa) Using the ADAM Model (Simcyp v7.1)

Author(s): S. Polak, M. Jamei, D. Turner, G. T. Tucker, A. Rostami-Hodjegan
Year:

Supersaturation Properties of Poorly Soluble Weak Bases are Key Factors in Determining Oral Drug Absorption: A Simulation Study of Nifedipine Using the ADAM Model (Simcyp v7.1)

Author(s): D. Turner, M. Jamei, G. T. Tucker, A. Rostami-Hodjegan
Year:

Mechanistic Models of Human Pharmacokinetics to Predict the Effects of Liver Cirrhosis on the Clearance of Nine Drugs

Author(s): T. N. Johnson, K. Boussery, S. Polak, G. T. Tucker, A. Rostami-Hodjegan
Year:

Cytochrome P450 Turnover: Methods for Determining Rates and Implications for the Prediction of Drug Interactions

Author(s): J. Yang, M. Liao, M. Shou, M. Jamei, K. R. Yeo, G. T. Tucker, A. Rostami-Hodjegan
Year:

Simulation of the Effect of P-glycoprotein on Drug Absorption in the Human Gastrointestinal Tract

Author(s): S. Neuhoff, J. Yang, M. Jamei, G. T. Tucker, A. Rostami-Hodjegan
Year:

In Vitro-In Vivo Extrapolation of the Clearance of Drugs by Glucuronidation: Scaling Factors for Recombinant UGT1A1 Data

Author(s): S. Neuhoff, Z. E. Barter, K. Rowland-Yeo, G. T. Tucker, A. Rostami-Hodjegan
Year:

Prediction of the In Vivo Behaviour of Modified Release Formulations of Metoprolol from In Vitro Dissolution Profiles Using the ADAM Model (Simcyp v8)

Author(s): S. Polak, M. Jamei, D. B. Turner, J. Yang, S. Neuhoff, G. T. Tucker, A. Rostami-Hodjegan
Year:

Comparison of the Catalytic Activity per Unit Enzyme of Recombinantly Expressed and Human Liver Microsomal Cytochrome P450 2C9: Determination of Inter System Extrapolation Factors

Author(s): H. K. Crewe, Z. E. Barter, K. Rowland-Yeo, G. T. Tucker, A. Rostami-Hodjegan
Year:

What is the Level of Expression of CYP2D6 in Human Liver? Influence of Different Calibration Standards on the Estimation of CYP2D6 Abundance

Author(s): H. F. Perrett, Z. E. Barter, M. S. Lennard, G. T. Tucker, A. Rostami-Hodjegan
Year:

Prediction of the Increased Exposure to Drugs in Liver Cirrhosis: A Systems Biology Approach Integrating Prior Information on Disease with In Vitro Data on Drug Disposition

Author(s): T. N. Johnson, K. Boussery, G. T. Tucker, A. Rostami-Hodjegan Hodjegan
Year:

Prediction of Time-dependent CYP3A4-mediated In Vivo Drug-drug Interactions from In Vitro Data Using Biological Information on Enzyme Turnover Implemented within a Physiologically-based Model

Author(s): K. Rowland-Yeo, M. Jamei, J.Yang, G.T.Tucker, A. Rostami-Hodjegan
Year:

Theoretical Assessment of Metabolic Drug Interactions in Pediatric Population: The Impact of Age Related Fractional Metabolism (fm) and Its Disparity between Adults and Neonates

Author(s): F. Salem, Z. E. Barter, T. N. Johnson, A. Rostami-Hodjegan
Year:

Comparison of the “Well-stirred” Gut and the “QGut” Models for Predicting Intestinal First-pass Metabolism

Author(s): J. Yang, M. Jamei, K. Rowland-Yeo, M. D. Harwood, G. T. Tucker, A. Rostami-Hodjegan
Year:

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