Biokinetic and PBPK modelling to support the rotenone and strobilurin read across case studies (CS4)

Author(s): Iain Gardner, Sofia Ferreira, Dennis Reddyhoff, Richard Maclennan, Ciarán Fisher
Year:

INVESTIGATING THE IMPACT OF ENZYME CORRELATIONS ON INTER-INDIVIDUAL VARIABILITY IN PHARMACOKINETICS AND DRUG-DRUG INTERACTIONS

Author(s): O Hatley, U Ezuruike, J Wedagedera, R Takahashi, J Mao, I Gardner
Year:

Evaluation of maternal drug exposure following the administration of antenatal corticosteroids during late pregnancy using PBPK Modeling

Author(s): Alice Ban Ke, Mark A. Milad
Year:

Performance Verification and Application of a Cancer population for use in Physiologically Based Pharmacokinetic modelling

Author(s): Nika Khoshaein, Udoamaka Ezuruike, Oliver Hatley, Kate Gill, Iain Gardner
Year:

Predicting the Concentration of PARP Inhibitors in Human Tumor Tissue Using PBPK Modeling

Author(s): Rachel H. Rose, Kaiming Sun, Linzhong Li, Keyur Gada, Jing Yu Wang, Yongchang Qiu
Year:

Development of a PBPK model for topical lidocaine in order to predict systemic absorption in healthy volunteers, geriatrics and paediatrics

Author(s): Farzaneh Salem, Nikunjkumar Patel, Sebastian Polak.
Year:

A Population-based PBPK Model for the Prediction of Time-varying Bile Salt Disposition within GI Luminal Fluids – Toward a Mechanistic Model

Author(s): Konstantinos Stamatopoulos, Shriram M. Pathak, David B. Turner
Year:

Propofol: A Tail of Drug Disposition and Dynamics in Different Dog Breeds

Author(s): Tariq Abdulla, Devendre Pade, Sibylle Neuhoff, Masoud Jamei
Year:

The Molecular Stethoscope: RNA of Drug Metabolising Enzymes in Circulating Vesicles Correlates with their Specific Protein Content in the Liver

Author(s): Brahim Achour, Zubida M Al-Majdoub, Kristi Lea, Jeoffrey Schageman, Amin Rostami-Hodjegan
Year:

Quantification of Human Blood-Brain Barrier Transporters in Health and in Dementia by Global and Targeted Proteomics

Author(s): Zubida M. Al-Majdoub, Hajar Al Feteisi, Brahim Achour, Stacey Warwood, Sibylle Neuhoff, Amin Rostami-Hodjegan, Jill Barber
Year:

Estimation of Effective pKa of Bicarbonate Buffer

Author(s): Siri Kalyan Chirumamilla, David B. Turner, Masoud Jamei
Year:

Physiological verification of a geriatric population using the Simcyp R package

Author(s): Liam Curry, Oliver Hatley
Year:

Accounting for CYP2C19 mechanism based inhibition and CYP1A2 induction in a PBPK model for omeprazole

Author(s): Udoamaka Ezuruike, Kate Gill, Peter Kilford and Iain Gardner
Year:

Biopharmaceutic In Vitro In Vivo Extrapolation (IVIV_E) Informed PBPK Model of Ritonavir Norvir® Tablet Absorption in Humans Under Fasted and Fed State Conditions

Author(s): Sumit Arora, Amita Pansari, Masoud Jamei, Iain Gardner, David B. Turner
Year:

Use of a physiologically based pharmacokinetic – pharmacodynamic (PBPK-PD) model to guide dose adjustments to S-warfarin in different populations

Author(s): Udoamaka Ezuruike, Helen Humphries, Khaled Abduljalil, Sibylle Neuhoff
Year:

Prediction of mAb disposition in hepatic impairment – Evolocumab as a case study

Author(s): Kate Gill, Iain Gardner
Year:

Quantitative Systems Toxicology Approach Integrates Simcyp PBPK and Core Hepatocyte Metabolism: a Case Study with Valproic Acid

Author(s): Vipul Gupta, Christian Maass, Richard MacLennan, Paul Walker, Jo Wilcock, Andrzej Kierzek, Jeremy Craven, Ciarán Fisher
Year:

The Certara Quantitative Systems Toxicology & Safety (QSTS) Pharma Consortium: Overview and Invitation to Join

Author(s): Mark Holbrook, Mitra Abbasi, Jeremy Craven, Sofia Ferreira, Ciarán Fisher, Vipul Gupta, Sebastian Polak, Dennis Reddyhoff, Zofia Tylutki, Will Redfern
Year:

Development of a PBPK model for the prediction of Amiodarone pharmacokinetics in fed and fasted state using ADAM model

Author(s): Peter Kilford, Xian Pan, Sumit Arora, Iain Gardner
Year:

Prediction of Drug-Drug Interaction between Phenobarbital and Theophylline in Children using Physiologically-Based Pharmacokinetic Modelling

Author(s): Xian Pan, Khaled Abduljalil, Trevor N. Johnson
Year: