Population Pharmacokinetic Analysis of DS-8201a, A HER2-Targeting Antibody-Drug Conjugate, in Patients with HER2-Positive Breast Cancer or Other Solid Tumors

Author(s): Ophelia Yin, Yuan Xiong, Seiko Endo, Kazutaka Yoshihara, Malaz AbuTarif, Russ Wada, Frank LaCreta
Year:

Integration of a Tumour Growth Inhibition Model within a Mouse Physiologically-Based Pharmacokinetic Model

Author(s): Khaled Abduljalil, Rachel H. Rose, Devendra Pade, Siri Kalyan Chirumamilla, Cong Liu, Isha Taneja, Anthonia Afuape, Linzhong Li, Iain Gardner
Year:

Mechanistic models of cancer Mechanistic models cancer-immune cycle and immunotherapies

Author(s): Viji Chelliah, Georgia Lazarou, Andrzej Kierzek, Piet van der Graaf
Year:

Development of Paclitaxel PBPK Model to Predict Tumour Concentration in Cancer Patients

Author(s): Siri Kalyan Chirumamilla, Rachel H. Rose, Khaled Abduljalil, Devendra Pade, Cong Liu, Isha Taneja, Anthonia Afuape, Linzhong Li, Iain Gardner
Year:

Transporter inhibition: modelling in-vitro Transwell Assays

Author(s): Mailys De Sousa Mendes, Matthew Harwood, Howard Burt, Sibylle Neuhoff
Year:

Development and Performance Evaluation of a semi-mechanistic PBPK Model for Topical Ocular Delivery of Pilocarpine and Timolol to Rabbit Eye

Author(s): Anam Fayyaz, Veli-Pekka Ranta, Eva Del Amo Paez, Iain Gardner, Arto Urtti, Masoud Jamei
Year:

Investigating Impacts of Model Parameters Correlations in Global Sensitivity Analysis: Determining the Most Influential Parameters of a Minimal PBPK Model of Midazolam

Author(s): Dan Liu, Linzhong Li, Amin Rostami-Hodjegan, Masoud Jamei
Year:

Pharmacodynamics of rituximab on B cells in paediatric post-HSCT patients with EBV

Author(s): Soumya Perinparajah, Juliana Silva, Austen Worth, S.Y. Amy Cheung, James W.T. Yates, Nigel Klein, Judith Breuer, Paul Veys, Persis J. Amrolia, Joseph F. Standing
Year:

Population Pharmacokinetics of Piperacillin-Tazobactam Extended Infusions in Paediatric Population

Author(s): Jean Lavigne, Nastya Kassir, Céline Thibault, Catherine Litalien, Julie Autmizguine
Year:

Modelling Toxicodynamic Feedback is Critical in Recovering Toxicokinetics in Acetaminophen Overdose

Author(s): D. Reddyhoff, C. Fisher, I. Gardner
Year:

T4.1 – Setting the framework for database and development of this database

Author(s): Kristin Lacy, Steve Andrews, Phil Hayward, Xavier Pepin
Year:

What Sample Size to Use When Designing Paediatric Pharmacokinetic Studies? A Critical Analysis of “Precision Criteria”

Author(s): Farzaneh Salem, Kayode Ogungbenro, Pavan Vajjah, Trevor N Johnson, Leon Aarons, Amin Rostami-Hodjegan
Year:

Application of a PBPK model for prediction of the DDI between Lorazepam and Probenecid.

Author(s): Helen Musther, Sibylle Neuhoff, Karen Rowland Yeo
Year:

Establishing an In Vitro-In Vivo Correlation (IVIVC) for Tramadol Extended-Release Tablets : Conventional vs. Physiologically Based IVIVC

Author(s): S. Pathak, N. Patel, D.Turner, M. Jamei, A. Rostami-Hodjegan
Year:

Simulating the effect of anti-diabetic drugs on ATP-sensitive potassium (KATP) channels inhibition in a human cardiac cell model (ORd)

Author(s): Mitra Abbasi, Sebastian Polak
Year:

Prediction of Enfuvertide Concentration-Time Profile in a Paediatric Population after Parenteral Administration Using a Physiologically Based Pharmacokinetic Model

Author(s): K. Abduljalil, K. Gill, F. Stader, T. Johnson, I. Gardner
Year:

Prediction of Midazolam Concentration Profile in Obese Adolescent Population Using Physiologically Based Pharmacokinetic model

Author(s): K. Abduljalil, T. Johnson, M. Jamei
Year:

Prediction of Midazolam Pharmacokinetics in Pregnant Women with Coeliac Disease using Simcyp Pregnancy PBPK Model

Author(s): K. Abduljalil, T. Johnson, M. Jamei
Year:

Prediction of Prothrombin Time after Oral Administration of S-Warfarin in Different CYP2C9 Phenotypes in Asian and Caucasian populations using the Simcyp Simulator

Author(s): K. Abduljalil, T. Johnson, M. Chetty, M. Jamei
Year:

DEVELOPMENT OF A PBPK MODEL FOR EFAVIRENZ THAT ACCOUNTS FOR AUTO-INDUCTION AND ITS EFFECT ON THE CYP2B6 SUBSTRATE BUPROPION

Author(s): Lisa M Almond, Alice Ke, Zoe E Barter, Karen Rowland-Yeo
Year:

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