The Use of Recombinantly Expressed Standards for Immuno-quantification of Hepatic CYP3A5 Can Result in an Underprediction of CYP3A5 Abundance

Author(s): H. F. Perrett, Z. E. Barter, R. J. Edwards, M. S. Lennard, A. Rostami-Hodjegan, G. T. Tucker
Year:

Prediction of Non-specific Hepatic Microsomal Binding from Readily Available Physicochemical Properties

Author(s): D. B. Turner, A. Rostami-Hodjegan, G. T. Tucker, K. R. Yeo
Year:

The Propagation of Genetic Polymorphism in CYP2C9 into Tolbutamide Pharmacokinetics: Assessment Using an Integrated Model

Author(s): G. L. Dickinson, M. S. Lennard, G. T. Turner, A. Rostami-Hodjegan
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Prediction of the Oral Clearance of S-warfarin in CYP2C9 Genotypes from In Vitro Enzyme Kinetic Data

Author(s): L. M. Almond, K. Rowland-Yeo, E. M. Howgate, G. T. Tucker, A. Rostami-Hodjegan
Year:

Predicting Drug Interactions with Selective Serotonin Reuptake Inhibitors (SSRIs): Impact of Non-binding and Active Uptake

Author(s): A. Heydari, K. Rowland-Yeo, M. S. Lennard, G. T. Tucker, A. Rostami-Hodjegan
Year:

Mechanism-based Inactivation of CYP2D6 by Methylenedioxymethamphetamine (MDMA): Differences Between Expressed Enzyme Systems and Human Liver Microsomes

Author(s): L. M. Van, J. A. Hargreaves, K. Rowland-Yeo, M. S. Lennard, G. T. Tucker, A. Rostami-Hodjedan
Year:

Differences in Cytochrome P450 (CYP3A4) Expression Alone Do Not Explain Inter-individual Variability in CYP3A Mediated Hepatic Testosterone 6ß Hydroxylase (TST6ßOH) Activity

Author(s): Z. E. Barter, K. H. Crewe, J. R. Harlow, Y. Lei, G. T. Tucker, and A. Rostami-Hodjegan
Year:

Estimation of the Kinetic Parameters of Mechanism-based Inhibition of CYP2D6 by Methylenedioxymethamphetamine (MDMA) in Cryopreserved Cryopreserved Human Hepatocytes

Author(s): L. M. Van, C. Hammond, J. Swales, C. Wilson, A. Rostami-Hodjedan, J. A. Hargreaves
Year:

In Vitro Stability of Human Recombinant Cytochrome P450 Enzymes

Author(s): J. Yang, G. T. Tucker, A. Rostami-Hodjegan
Year:

Co-operativity in the In Vitro Kinetics of Cytochrome P450 (CYP) Mediated Drug Metabolism Will Have Minimal Impact on In Vivo Metabolic Clearance

Author(s): M. Jamei, J. Yang, A. Rostami-Hodjegan, G. T. Tucker
Year:

Prediction of the Inhibitory Effects of Ketoconazole and Fluconazole on Midazolam and Zolpidem Clearance from In Vitro Data Using Physiologically-based Pharmacokinetic Modeling

Author(s): K. Rowland-Yeo, M. Jamei, J. Yang, G. T. Turner, A. Rostami-Hodjegan
Year:

A Meta-analysis of CYP3A4 Abundance in Human Liver: Use of Different Standards Contributes to Apparent Heterogeneity in Reported Values

Author(s): Z. E. Barter, K. Rowland-Yeo, G. Tucker, A. Rostami-Hodjegan
Year:

The Impact of Ketoconazole (KTZ) Dosage Regimen on Midazolam Clearance and Its Prediction Using PBPK Modeling

Author(s): M. Ozdemir, H. K. Crewe, G. T. Tucker, A Rostami-Hodjegan
Year:

Prediction of Metabolic Drug Clearance in Pediatric Subjects and Its Sensitivity to Different Models of the Development of CYP Enzymes

Author(s): T. N. Johnson, G. T. Tucker, A. Rostami-Hodjegan
Year:

Assessing the Propagation of CYP2C9 Polymorphisms into the PK/PD of (S)-warfarin Using Clinical Trial Simulations (CTS)

Author(s): G. L. Dickinson, M. S. Lennard, G. T. Turner, A. Rostami-Hodjegan
Year:

Utility of Data from Recombinant Expressed Genetic Variants of CYPs in Predicting the Influence of Genotype on In Vivo Drug Kinetics: The Case for S-Warfarin

Author(s): L. M. Almond, K. Rowland-Yeo, E. M. Howgate, G. T. Tucker, A. Rostami-Hodjegan
Year:

Prediction of the Oral Clearance of Midazolam Using In Vitro Data from Recombinantly Expressed Enzymes and Inter System Extrapolation Factors

Author(s): Z. E. Barter, K. Rowland-Yeo, E. M. Howgate, G. Tucker, A. Rostami-Hodjegan
Year:

Prediction of the Oral Clearance of Tolbutamide in Individuals with Different CYP2C9 Genotypes Using In Vitro Enzyme Kinetic Data

Author(s): L. M. Almond, K. Rowland-Yeo, G. L. Dickinson, E. M. Howgate, G. T. Tucker, A. Rostami-Hodjegan
Year:

Prediction of the Oral Clearance of Midazolam Using In Vitro Data from Recombinantly Expressed Enzymes and Inter System Extrapolation Factors

Author(s): Z. E. Barter, K. Rowland-Yeo, E. M. Howgate, G. T. Tucker, A. Rostami-Hodjegan
Year:

Mechanistic Prediction of HIV Drug-drug Interactions in Virtual Populations from In Vitro Enzyme Kinetic Data: Ritonavir and Saquinavir

Author(s): L. Almond, K. Rowland-Yeo, E. Howgate, G. T. Tucker, A. Rostami-Hodjegan
Year:

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