Pharmacokinetics of WCK 2349 in Healthy Indian Male Adults under Fasting Conditions

Author(s): J. Niu, V. Ivaturi, J. Gobburu, R. Chugh, A. Bhatia
Year:

Pharmacokinetics of Intravenous WCK 771 in Healthy Indian Male Adults

Author(s): J. Niu, V. Ivaturi, J. Gobburu, R. Chugh, A. Bhatia
Year:

Population Pharmacokinetics of Acetaminophen in Acute Overdosed Patients to Derive a New Risk Metric for Antidote Administration

Author(s): J. Desrochers, W. Klein-Schwartz, S. Doyon, M.Gopalakrishnan
Year:

Pharmacokinetics of WCK 2349 in Patients with Complicated Skin & Soft Tissue Infections (cSSTIs) Caused by Gram Positive Bacteria Including MRSA

Author(s): S. Mehrotra, V. Ivaturi, J. Gobburu, R. Chugh, A. Bhatia
Year:

Pharmacokinetics of Intravenous WCK 771 in Healthy US Adults

Author(s): S. Mehrotra, V. Ivaturi, J. Gobburu, R. Chugh, A. Bhatia
Year:

Weight Based Dosage Adjustments Are Not Required for WCK 771, a Novel Broad-spectrum Floroloquinolone

Author(s): D. Pastoor, J. Gobburu, R. Chugh, A. Bhatia, V. Ivaturi
Year:

Inter- and Intra-individual Variability in Physiological Parameters of Gastro-intestinal Tract Has Significant Effects on the Predicted Fraction of Dose Absorbed

Author(s): M. Jamei, J. Yang, A. Rostami-Hodjegan
Year:

Genetic Algorithms and Their Applications in PK/PD Data Analysis

Author(s): M. Jamei, J. Yang, K. Yeo, G. T. Tucker, A. Rostami-Hodjegan
Year:

Inter- and Intra-individual Variability in Gastro-intestinal Physiology Has Significant Effects on the Prediction of the Fraction of Dose Absorbed (fa)

Author(s): M. Jamei, J. Yang, A. Rostami-Hodjegan, G. T. Tucker
Year:

Inter-individual Variability in the Catalytic Activity of CYP3A4 Per Unit of Enzyme (kcat)

Author(s): Y. Lei, Z. E. Wilson, K. H. Crewe, G. T. Tucker, A. Rostami-Hodjegan
Year:

A Critical Evaluation of the Experimental Design in Reports of Mechanism Based Inhibition (MBI) Studies and the Assessment of Their Implication for In Vitro-In Vivo Extrapolation (IVIVE)

Author(s): F. Ghanbari, K. Rowland-Yeo, G. T. Tucker, A. Rostami-Hodjegan
Year:

The Propagation of Genetic Polymorphism In CYP2C9 Into Warfarin Pharmacokinetics: An Integrated Model

Author(s): G. L. Dickinson, M. S. Lennard, G. T. Turner, A. Rostami-Hodjegan
Year:

Prediction of Xenobiotic Clearance in Humans: In Vitro-In Vivo Extrapolation (IVIVE) vs Allometric Scaling (AS)

Author(s): M. R. Shiran, N. J. Proctor, E. M. Howgate, K. Rowland-Yeo, G. T. Tucker, A. Rostami-Hodjegan
Year:

The Impact of Study Design on the Estimation of Parameters Describing Mechanism-based Enzyme Inhibition

Author(s): A. Heydari, K. Rowland-Yeo, M. S. Lennard, G. T. Tucker, A. Rostami-Hodjegan
Year:

Incorporation of Inter-individual Variability into the Prediction of In Vivo Drug Clearance from In Vitro Data

Author(s): E. M. Howgate, K. Rowland-Yeo, N. J. Proctor, A. Rostami-Hodjegan. G. T. Tucker
Year:

Implications of the Disparity in Relative Holo:Apo-protein Contents of Different Standards Used for Immuno-quantification of Hepatic P450 3A4 (CYP3A4)

Author(s): Z. E. Wilson, S. W. Ellis, R. J. Edwards, G. T. Tucker, A. Rostami-Hodjegan
Year:

Simulations to Assess the Propagation of the Impact of Genetic Polymorphism in CYP Enzymes into PK and PD Outcomes: Warfarin and Dextromethorphan as Examples

Author(s): G. L. Dickinson, M. S. Lennard, G. T. Turner, A. Rostami-Hodjegan
Year:

Values of Human Hepatocellularity Per Gram of Liver and Associated Variability for Use in the Prediction of Human In Vivo Metabolic Clearance

Author(s): Z. E. Barter, J. L. Burn, G. T. Tucker, A. Rostami-Hodjegan
Year:

The Impact of Dose-staggering on the Inhibitory Effect of Ketoconazole on Midazolam Clearance, and Its Prediction Using Physiologically-based Pharmacokinetic Modeling

Author(s): M. Ozdemir, H. K. Crewe, G. T. Tucker, A. Rostami-Hodjegan
Year:

Modeling of the Age Related Changes of Human CYP Enzymes for Predicting Drug Disposition in Neonates, Infants and Children

Author(s): T. N. Johnson, G. T. Tucker, A. Rostami-Hodjegan
Year:

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