The Fantastic 4: Simcyp Rat, Mouse, Dog, and Monkey Simulators

On-Demand Webinar
Physiologically-based pharmacokinetic (PBPK) modeling and simulation has been regularly used to translate information from animals to humans to assist in dose selection and ‘First-in-Human’ studies. Certara’s animal PBPK platform, the Simcyp®️ Animal Simulators (SAS) include PBPK models for pre-clinical species such as the mouse, rat, dog, and monkey.
Since it is common to obtain drug specific in vitro and in vivo experimental data in pre-clinical species, the SAS can help us to understand the complex processes of ADME (absorption, distribution, metabolism, and excretion) and develop pharmacokinetic/pharmacodynamic (PK/PD) relationships that can be translated to humans.
Watch this webinar with Dr. Devendra Pade to learn more about the Simcyp Animal Simulators, and the role they play in developing safer and more effective medications in the human and veterinary drug development arena.

 

About Our Speaker

Devendra Pade is a Senior Research Scientist in Certara’ UK (Simcyp Division’s) modeling and simulation group. He received his PhD in the Prediction of Oral Drug Absorption and Pre-Clinical Pharmacokinetics with the Stavchansky group from The University of Texas at Austin. Since joining Simcyp in 2009, he has worked on various projects in PBPK modeling with a major interest in oral drug absorption and development of animal PBPK models for preclinical species such as rat, beagle dog, mouse and cynomolgus monkey. As part of the oral absorption team, he was also involved with the development of the mechanistic permeability model and the application of Simcyp Simulator’s oral absorption (ADAM) model to evaluate the impact of various weight loss surgeries on the pharmacokinetics of different drugs in obese and bariatric surgery individuals.