Simcyp Workshop: Model-informed Drug Development

July 31, 2017

Delegates will learn how to simulate metabolic drug clearance (CL), metabolic drug-drug interactions (DDIs), gut first-pass metabolism, oral drug absorption incorporating food effects and the impact of dosage form, the effects of transporters and enterohepatic recirculation on kinetics and DDIs, drug distribution to different organs, population variability in drug concentration-time profiles, the variation in kinetics in specific populations (pediatrics, ethnic groups, various disease populations), data for therapeutic proteins, pharmacodynamic effects of different compounds, and time-course of drug in plasma that fits observed clinical data (achieved by combining fitting techniques with IVIVE, PBPK and drug specific in vitro data).

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