Re-evaluation of a quantitative structure pharmacokinetic model for biliary excretion in rats

Quantitative structure pharmacokinetic relationship (QSPKR) modeling can be used to predict the biliary clearance and percentage of dose eliminated in bile (PDb) in humans before clinical studies. Recently, a QSPKR model based on in-house compounds was derived using simple physicochemical descriptors to predict the PDb in rats.

Yash A. Gandhi, Marilyn E. Morris
July 1, 2012
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