N-1H-benzimidazol-5-ylbenzenesulfonamide derivatives as potent hPXR agonists

The Human Pregnane X Receptor (hPXR) is a nuclear receptor that regulates the expression of phase I and phase II drug-metabolizing enzymes, as well as that of drug transporters. Because this receptor plays a critical role in protecting tissues from potentially toxic endo- and xenobiotics, highly active agonists could represent novel therapeutic tools in treating several human diseases.

Cindy Benod, Guy Subra, Virginie Nahoum, Aude Mallavialle, Jean-François Guichou, Julien Milhau, Samuel Roblés, William Bourguet, Jean-Marc Pascussi, Alain Chavanieu
April 1, 2008
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