Identification of small molecules that inhibit GSK-3β through virtual screening

Glycogen synthase kinase-3β (GSK-3β) is involved in glycogen metabolism, neuronal cell development, osteoblast differentiation. Small molecule inhibitors of GSK-3β have various therapeutic potential for the treatment of diabetes type II, bipolar disorders, stroke and chronic inflammatory disease.

 

Nam Sook Kang, Gil Nam Lee, Chi Hyun Kim, Myung Ae Bae, Ikyon Kim, Young Sik Cho
January 15, 2009
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