Identification of novel potent inhibitors against Bcl-xL anti-apoptotic protein using docking studies

Bcl-xL protein belongs to BCL-2 family which has either pro- or anti-apoptotic activities owing to their importance in the regulation of apoptosis, tumor genesis and cellular responses to anti-cancer therapy. Bcl-xL permeabilize the outer mitochondrial membrane of cells and inhibit these processes.

Gupta Shipra, Misra Gauri, Pant Mohan Chandra, Seth Prahlad Kishore
December 1, 2012
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