CoMSIA study on substituted aryl alkanoic acid analogs as GPR40 agonists

GPR40, a G-protein-coupled receptor has been well established to play a crucial role in regulating blood glucose levels. Hence, GPR40 is a potential target for future antidiabetic agents. The present 3D QSAR study is aimed at delineating structural parameters governing GPR40 agonistic activity.

Aaditya Bhatt, Pallav D. Patel, Maulik R. Patel, Satyakam Singh, Cesar A. Lau-Cam, Tanaji T. Talele
May 1, 2011
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